三、主要科研工作与成绩 主要从事食品危害物、疾病标志物的检测技术及产品的研发工作。近年来主持了国家级项目3项、上海市科/农/卫健委科研项目及企事业委托项目9项；相关研究成果发表论文50余篇，申请发明专利13项，获授权7项，分别获得上海市技术发明一等奖、二等奖。 近期部分主持的科研项目： 国家重点研发计划国际合作专项：阿尔茨海默病早期血液生物标志物检测方法及产品开发 国家重点研发计划：基于机器视觉的食品链重金属及农药高通量传感监测系统 上海市项目：利用智能图像识别地产果蔬中多污染物的高通量传感监测系统的研制与应用 上海市项目：水产养殖全过程的重金属污染快速精准监测体系的构建及其示范应用 上海市项目：基于适配体分子识别和纸基微流控技术的果蔬中重金属高通量速测试剂盒的研制 近期代表性论文： 1.Min Yuan, Xinyan Huan, Xiaojun Yang, Menghan Fan, Jiaqi Yin, YingQing Ma, Bo Deng, Hui Cao, Yiyi Han*, Fei Xu*. Simultaneous extraction of five heavy metal ions from root vegetables via dual-frequency ultrasound-assisted enzymatic digestion. Food Chemistry, 2024, 454, 139741. 2.Min Yuan, Chen Li, Yuzhu Zheng, Hui Cao, Tai Ye, Xiuxiu Wu, Liling Hao, Fengqin Yin, Jinsong Yu, Fei Xu*. A portable multi-channel fluorescent paper-based microfluidic chip based on smartphone imaging for simultaneous detection of four heavy metals. Talanta, 2024, 266, 125112. 3.Min Yuan, Shiquan Qian, Hui Cao, Jinsong Yu, Tai Ye, Xiuxiu Wu, Limin Chen, Fei Xu*. An Ultra-sensitive electrochemical aptasensor for simultaneous quantitative detection of Pb2+ and Cd2+in fruit and vegetable. Food Chemistry. 2022, 382, 132173.ESI 4.Shiquan Qian1, Yiyi Han1, Fei Xu, Dongsheng Feng, Xiaojun Yang, Xiuxiu Wu, Liling Hao, Min Yuan*. A fast, sensitive, low-cost electrochemical paper-based chip for real-time simultaneous detection of cadmium (II) and lead (II) via aptamer. Talanta. 2022, 247: 123548. 5.Min Yuan, Chen Li, Mengxue Wang,Hui Cao, Tai Ye, Liling Hao, Xiuxiu Wu, Fengqin Yin, Jinsong Yu, Fei Xu*. Low-cost, portable, on-site fluorescent detection of As(III) by a paper-based microfluidic device based on aptamer and smartphone imaging. Microchimica Acta. 2023,190(3):109.
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