姓名 | 顾雪锋 | |
工作单位 | 上海健康医学院 | |
职称 | 副教授 | |
导师资格 | 硕士研究生指导教师 | |
学科专业 | 肿瘤分子生物学及大数据生物信息学 | |
联系方式 | 电话：18602197911 E-mail：guxf@sumhs.edu.cn | |
一、个人简介 硕导，哈尔滨工业大学本科和硕士，韩国首尔大学博士，主要从事恶性肿瘤的发生发展及侵袭转移,医学大数据分析挖掘，生物信息学等相关研究。主持过黑龙江省科技攻关项目，哈尔滨市青年科学基金，广东省自然科学基金项目，上海市科技支撑项目，参与过国家863重大专项计划，国自然等项目研究,连续两年获得广东省扬帆计划人才资助，获得发明专利6项，发表SCI论文20多篇，其中发表于神经肿瘤学权威杂志Neuro-Oncology（IF=10.091）的工作被他引34次。 XUEFENG GU received the B.S. degree and the master’s degree in biotechnology from the Harbin Institute of Technology (HIT), China, in 2001 and 2004, and the Ph.D. degree in dental science from Seoul National University (SNU), South Korea, in 2009. He is currently a researcher with the Shanghai Key Laboratory of Molecular Imaging, Collaborative Research Center, Shanghai University of Medicine and Health Sciences (SUMHS), China. His current research interests include the role of the different signaling pathways in cancer, bioinformatics in biology and medicine and some important tumor-related genes in occurrence and development of malignant tumors. | ||
二、主要学习与工作经历 教育背景： 2006/03-2009/06，韩国首尔大学，分子生物学，博士，导师：李宗镐 2001/09-2004/01，哈尔滨工业大学，分子生物学，硕士，导师：朱大海 1997/09-2001/07，哈尔滨工业大学，生命科学与工程系，学士 工作经历： 2017/11-至今，上海健康医学院，上海市分子影像重点实验室，讲师，硕导 2016/01-2017/10，广东医科大学，神经病学研究所，助理研究员 2013/01-2015/12，广东医科大学，神经病学研究所，博士后 | ||
三、主要科研工作与成绩 论文发表： (1) WH Huang*, XF Gu*, YY Wang*, YH Bi, Y Yang, GQ Wan, NH Chen, KS Li. Effects of the co-administration of MK-801 and clozapine on MiRNA expression profiles in rats. Basic Clin Pharmacol Toxicol. 2021 Mar 3. doi: 10.1111/bcpt.13576. (2) YJ Zheng , GQ Wan, B Yang, XF Gu#, JR Lin#. Cardioprotective Natural Compound Pinocembrin Attenuates Acute Ischemic Myocardial Injury via Enhancing Glycolysis. Oxid Med Cell Longev. 2020 Oct 15;2020: doi: 10.1155/2020/4850328. (3) DS Liu, XJ Zuo, P Zhang, R Zhao, DL Lai, KJ Chen, YR Han, GQ Wan, YJ Zheng# , CL Lu#, XF Gu#. The Novel Regulatory Role of lncRNA-miRNA-mRNA Axis in Amyotrophic Lateral Sclerosis: An Integrated Bioinformatics Analysis.Comput Math Methods Med. vol. 2021. https://doi.org/10.1155/2021/5526179 (4) XF Gu*, GQ Wan*, Y Yang*, YH Liu, XT Yang, YJ Zheng, LY Jiang, P Zhang, DS Liu, WM Zhao, G Huang, CL Lu. SLFN5 influences proliferation and apoptosis by upregulating PTEN transcription via ZEB1 and inhibits the purine metabolic pathway in breast cancer. Am J Cancer Res. 2020 Sep 1;10(9):2832-2850. (5) Q Han, Y Fu, JM Le, A Pilot, S Cheng, PQ Chen, HL Wu, GQ Wan#, XF Gu#. Electroacupuncture may alleviate behavioral defects via modulation of gut microbiota in a mouse model of Parkinson's disease. Acupunct Med. 2021 Feb 8; (6) GQ Wan*, J Zhu*, XF Gu*, Y Yang, YH Liu, ZZ Wang, YX Zhao, HL Wu,G Huang, CL Lu. Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription. Br J Cancer. 2020 Jun 3. doi: 10.1038/s41416-020-0873-z. (7) XF Gu*, DY Jiang*, Y Yang, P Zhang, GQ Wan, WX Gu, JF Shi，LY Jiang, B Chen,YJ Zheng, DS Liu ,SF Guo, CL Lu. Construction and Comprehensive Analysis of Dysregulated Long Noncoding RNA-Associated Competing Endogenous RNA Network in Moyamoya Disease. Comput Math Methods Med. 2020 June 13, Doi:10.1155/2020/2018214 (8) Shen Y, Jia Y, Li Y, Gu X, Wan G, Zhang P, Zhang Y, Jiang L. Genetic determinants of gestational diabetes mellitus: a case-control study in two independent populations. Acta Diabetol. 2020 Feb 29. doi: 10.1007/s00592-020-01485-w. [Epub ahead of print]; (9) FJ Hao, JF Shi, YY Chen, XF Gu#, D Ma#. Integrated analysis of a noncoding RNAassociated competing endogenous RNA network in non-alcoholic fatty liver disease. IEEE Access PP(99):1-1，May 2020，DOI： 10.1109 /ACCESS. 2020.2992109 (10) Zhang P*, Wang J*, Zhang X*, Wang X, Jiang L, Gu X#. Identification of AIDS-Associated Kaposi Sarcoma: A Functional Genomics Approach. Front Genet. 2020 Jan 24;10:1376. doi: 10.3389/fgene.2019.01376. eCollection 2019. (11) Gu X*, Wan G*, Chen N*, Li J, Chen B, Tang Y, Gu W, Jin C, Meng J, Zhang P, Liu L, Yang Z, Lu C. DGKζ Plays Crucial Roles in the Proliferation and Tumorigenicity of Human glioblastoma. Int J Biol Sci. 2019; 15(9): 1872–1881. (12) Wan G, Liu Y, Zhu J, Guo L, Li C, Yang Y, Gu X, Deng LL, Lu C. SLFN5 suppresses cancer cell migration and invasion by inhibiting MT1-MMP expression via AKT/GSK-3β/β-catenin pathway. Cell Signal. 2019 Jul;59:1-12. Epub 2019 Mar 4. (13) 韩秋琴,万国庆,顾雪锋#，基于16S rRNA基因测序探讨鱼藤酮诱导的帕金森病模型小鼠体内肠道微生物的变化，解剖学报，2020.08, 508-513. (14) 岑学程,高力扬,陈兵,杨帆,龙霄翱,顾雪锋,李锦宏. GSK3对人脑胶质瘤增殖的影响及基因表达谱富集分析《广东医科大学学报》 2018.01. (15) 李锦宏,陈兵,顾雪锋#,马国达,杨帆,高力扬,廖壮槟,林亨,龙霄翱. 乙二醛酶1在脑胶质瘤组织中的表达《广东医学院学报》 2016.05. (16) 黄文辉,顾雪锋,李克深. 微小RNA在神经退行性疾病发病机制中作用的研究进展《山东医药》 2016.41. (17) Xuefeng Gu*, Ce Wang*, Xuefeng Wang*, Guoda Ma, You Li, Lili Cui, Yanyan Chen, Bin Zhao#, Keshen Li#, Efficient inhibition of human glioma development by RNA interference-mediated silencing of PAK5, Int J Biol Sci., 2015, 11(2): 230-7 (18) Xuefeng Gu*, Xuefeng Wang*, Hong Xiao*, Guoda Ma, Lili Cui, You Li, Haihong Zhou, Wandong Liang, Bin Zhao#,Keshen Li#, Silencing of R-Spondin1 increases radiosensitivity of glioma cells, Oncotarget, 2015, 6(12): 9756-65 (14) Xuefeng Gu*, Lifen Yao*, Guoda Ma, Lili Cui, You Li, Wandong Liang, Bin Zhao#, Keshen Li#, TCTP promotes glioma cell proliferation in vitro and in vivo via enhanced β-catenin/TCF-4 transcription, Neuro-Oncology, 2014, 16(2): 217-27 (15) Zheping FANG*, Beige Jiang*, Xuefeng Gu*, Bin Zhao, RuiLiang Ge#, Fabiao Zhang#, P21-activated kinase 5 plays essential roles in the proliferation and tumorigenicity of human hepatocellular carcinoma, Acta Pharmacol Sin, 2014, 35(1): 82-8 (16) Guoda Ma*, Haiyang Wang* , Xuefeng Gu, Wei Li, Xingli Zhang, Lili Cui, You Li, Yong Zhang, Bin Zhao#, Keshen Li#, CARP, a Myostatin-down regulated gene in CFM cells, is a novel essential positive regulator of myogenesis, Int J Biol Sci, 2014, 10(3): 309-20 (17) You Li*, Cheng Yang*, Guoda Ma, Lili Cui, Xuefeng Gu, Yanyan Chen, Bin Zhao, Haiyang Wang#, Li K#, Analysis of ADAM17 polymorphisms and susceptibility to sporadic abdominal aortic aneurysm, Cell Physiol Biochem, 2014, 33(5): 1426-38 (18) You Li*, Cheng Yang*, Guoda Ma, Xuefeng Gu, Min Chen, Yanyan Chen, Bin Zhao, Lili Cui #, Keshen Li #, Association of Polymorphisms of the Receptor for Advanced Glycation End Products Gene with COPD in the Chinese Population, DNA Cell Biol, 2014, 33(4): 1-8 (19) Hongjiang He, Xuefeng Gu, Wanhai Xu, Dejun Yang, Xiaomin Wang ,Yu Su#, Krüppel-like factor 8 is a novel androgen receptor co-activator in human prostate cancer, Acta Pharmacol Sin, 2013, 34(2): 282-8 (20) Wang HB, Wang QG, Zhang XY, Gu XF, Wang N, Wu SB, Li H. Microarray analysis of genes differentially expressed in the liver of lean and fat chickens. Animal (2010), 4:4, pp 513–522 (21) XueFeng Gu*, Jongho Lee, Sangbae Yoo, Youngwha Moon, Jeongwon Jahng#, Intra-oral pre-treatment with capsaicin increases consumption of sweet solutions in rats, Nutritional Neuroscience, 2009, 12(4): 149-154 (22) V Ryu, J-H Lee, SB Yoo, XF Gu, YW Moon and JW Jahng#.Sustained hyperphagia in adolescent rats that experienced neonatal maternal separation. Int J Obes (Lond). 2008;32(9):1355-62. (23) KS Li, DM Dong, LF Yao, DW Dai, XF Gu, L Guo#. Identification of STC1 as an beta-amyloid activated gene in human brain microvascular endothelial cells using cDNA microarray.Biochem Biophys Res Commun. 2008;376(2):399-40 (24) KS Li, DW Dai, LF Yao, XF Gu, K Luan,WJ Tian, YS Zhao, BY Wang#. Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population. Neurosci Lett. 2008;433(2):125-8 (25) Keshen Li, Xuefeng Gu, Ping Li, Yong Zhang, Yashuang Zhao, Zhenjiang Yao, Naiqiang Qu, Binyou Wang#, Effect of pseudolaric acid B on gastric cancer cells: Inhibition of proliferation and induction of apoptosis, World Journal of Gastroenterology, 2005, 11(48): 7555-7559 (26) 高兴春,顾雪峰,韩俊,基于电子克隆方法获得鸡MIBP全长cDNA,生物信息学,2005,(02):58-61 会议论文： (1) Xuefeng Gu, Vitaly Ryu, Seoul Lee, Jong Ho Lee, Jeong Won Jahng. Repeated exposure to capsaicin increases sucrose drinking and gene expression of sweet taste receptors in rats.Appetite (2006) 46; 357 (2) Xuefeng Gu, Jong-Ho Lee, Ke-Shen Li, JW Jahng. Gene Expression Profiles of As2O3-Treated Cervical Cancer Hela Cells.Proceeding of the 5th International Forum on Post-Genome Technologies. 2007;5(1)：357-360. (ISTP, UT ISIP:000251162700127). 授权发明专利： 人PBX1基因的用途及其相关药物,2016.01.13，中国，ZL201210005699.1 人CIT基因的用途及其相关药,2019.03.26，中国，ZL201210162600.9 人CUL4B基因的用途及其相关药物,2018.08.07，中国，ZL201210313850.8 人IFITM3基因的用途及其相关药物,2018.03.27, 中国，ZL201210314142.6 人STIM1基因的用途及其相关药物,2015.07.08, 中国，ZL201110425916.8 人NLK基因相关的用途及其相关药物,2015.04.29, 中国，ZL201110440594.4 课题与项目： 1. 广东省自然科学基金项目，2016A030313680，翻译控制肿瘤蛋白TCTP对胶 质瘤细胞干性的影响及机制研究，2016/07-2019/06，10万元，已结题，主持； 2. 2016年广东省扬帆计划，2016年，12万元； 3. 2015年广东省扬帆计划，2015年，12万元； 4. 上海健康医学院协同创新重点专项，SLFN5在肿瘤转移中的作用及其分子网络调，控机制，2018/07-2020/07，100万元，参加； 5. 上海市委办局科研项目，研究外周血lncRNA与膝骨关节炎的关联研究，2019/01-2021/12，10万，参加； 6. 产学研横向课题，NK细胞来源外泌体靶向治疗脑胶质瘤的应用研究，2018/09-2021/08，15万，主持； 7. 教委教师发展工程，脑胶质瘤细胞来源外泌体的蛋白质组学分析，2020/04- 2020/12，5万，主持； 8. 优秀青教计划-市教委，思政教育在高等医学院校生物化学专业课教学中的有机融入，2019/06-2021/06，6万，主持； 9. 校级种子基金，PAK5通过AKT途径促进脑胶质瘤发生发展的机制研究，2018/01-2019/12，5万，主持； 10. 国家自然科学基金项目，81801833，tRNA羧甲基修饰酶Elongator在肺腺癌有丝分裂中的作用与分子机制研究，2019/01-2021/12，21万元，参加； | ||
四、主要社会学术团体兼职 神经肿瘤学会SNO会员； SSIB会员； AOCN会员； 上海市浦东新区周浦医院双聘人才；“健康医苗”创新创业指导教师； Frontiers in Genetics, Biomed Research International, Chronobiology International，Current Bioinformatics等SCI杂志论文评审专家 | ||
五、主要研究方向 1.大数据分析及生物信息学方向：偏工科方向，面对大量的生物及疾病相关数据累积，从全局和系统水平研究和分析生物学或者医学问题，它是当今自然科学交叉的重大前沿领域之一。毕业方向开阔：药企，各类生物医学相关高科技企业，大数据分析需求企业，高校，银行，保险，医院，或继续深造等； 2.肿瘤分子生物学：偏理学方向，基于大数据分析后的基因功能验证，分子机制研究，药物靶点筛选；毕业方向：生物企业，医院，或继续深造等； 3.产品研发：偏应用方向，生物功能蛋白的表达纯化；中医药保健品的应用研发；医疗器械的应用研发；微信小程序的应用研发； | ||
六、有合作项目的企业、医院、研究所等，以及合作项目名称 1.上海市周浦医院：生物信息学的临床疾病及相关大数据分析应用 2.上海锐赛生物技术有限公司：NK细胞来源外泌体靶向治疗脑胶质瘤的应用研究 3.上海万乘基因：新一代测序技术的应用研究及数据分析 4.中国移动上海移动通迅公司：移动大数据与疾病相关大数据的整合技术探讨 5.上海瑞金医院：单细胞测序在甲状腺癌的应用研究
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