三、主要科研工作与成绩 (一)代表性论文:一区7篇 Jingjing Zhang, Jinxin Qiu, Wenyong Zhou, Jianping Cao, Xuefei Hu, Wenli Mi, Bin He*, Ju Qiu* and Lei Shen*, Neuropilin-1 mediates lung tissue-specific control of ILC2s function in type 2 immunity, Nature Immunology. (Accept, IF=25.606,中科院一区) Yazhong Wei1, Minfang Zhu1, Saiqi Li1, Ting Hong, Xiaoyu Guo, Yongyong Li, Yiqiong Liu,Xumin Hou*, Bin He*. Engineered Biomimetic Nanoplatform Protects the Myocardium Against Ischemia/Reperfusion Injury by Inhibiting Pyroptosis. ACS Applied Material & Interfaces, 2021, 13:33756-33766. (IF=9.229, 中科院一区) Xiaoyu Guo1, Ting Hong1, Shen Zhang1, Yazhong Wei, Haizhen Jin, Qing Miao, Kai Wang, Miao Zhou, Chong Wang*, Bin He*. IL-13 Alleviates Cardiomyocyte Apoptosis by Improving Fatty Acid Oxidation in Mitochondria. Frontiers in Cell and Developmental Biology, 2021, 736603. (IF=6.684, JCR一区) Ting Hong1, Saiqi Li1, Xiaoyu Guo1, Yazhong Wei, Jingjing Zhang, Xiaohui Su, Shen Zhang1, Miao Zhou, Haizhen Jin, Qing Miao, Lei Shen, Minfang Zhu*, Bin He*.IL-13 Derived Type 2 Innate Lymphocytes Ameliorates Cardiomyocyte Apoptosis Through STAT3 Signaling Pathway. Frontiers in Cell and Developmental Biology, 2021, 742662. (IF=6.684, JCR一区) Li H1, Han S1, Lyu B, Hong T, Zhi S, Xu L, Xue F, Sai L, Yang J, Wang X*, He B*. Tunable light emission from carbon dots by controlling surface defects. Chinese Chemical Letters, 2021, 2887-92. (IF=6.779, JCR一区) Hong T,Wei Y, Xue X, Li Y,Dong H, Guo X,Shi X, He B. A Novel Anti-Coagulative Nanocomplex in Delivering miRNA-1 Inhibitor Against Microvascular Obstruction of Myocardial Infarction, Advanced Healthcare Materials, 2020, e1901783. (IF=9.993,中科院一区) Ji H, Wu G, Li Y, Wang K, Xue X, You S, Wu S, Ren T, He B, Shi X. Self-Albumin Camouflage of Carrier Protein Prevents Nontarget Antibody Production for Enhanced LDL-C Immunotherapy, Advanced Healthcare Materials, 2020,9(1):e1901203.(IF=9.993,中科院一区)
(二)代表性课题:国家级5项 国家自然科学基金面上项目《2型固有淋巴细胞促进心梗后心肌纤维化的作用及其活化的调控机制研究》(项目批准号:82072199,55万,2021-2024); 国家自然科学基金面上项目《双靶向纳米化miRNA-204治疗心肌缺血再灌注损伤的机制研究》(项目批准号:81470390,73万,2015-2018); 国家自然科学基金青年-面上连续项目《miRNA-204和miRNA-1对缺血再灌注损伤后的心肌自噬的调控机制研究》(项目批准号:81270003, 70万,2013-2016); 国家自然科学基金青年项目《miRNA-1和miRNA-133在缺血后处理的心肌保护机制中的调控作用研究》(项目批准号:30901470,19万,2010-2012); 国家教育部留学回国人员科研启动基金《自噬在硫化氢心肌保护中的作用及miRNA的调控作用》(项目批准号:教外司留〔2013〕1792,3万,2014-2016);
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