三、主要科研工作与成绩 *主持课题 1.促进市级医院临床技能与临床创新三年行动计划重大临床研究项目，新型骨质疏松性骨折预警管理体系建立及应用的临床研究，2020/10-2022/9，100万。 2.国家自然科学基金面上项目，82073207，PKCη-Rhot2信号轴调控线粒体稳态及肾透明细胞癌骨转移的机制和功能研究，2021/1-2024/12，57万元。 3.上海交通大学医工交叉项目，重点项目，ZH2018ZDA18，调控肿瘤微环境的光热纳米材料的制备及其在骨肿瘤光热治疗中的应用，2019-01至2021-12，100万元。 4.综合医院中西医结合专项课题,ZHYY-ZXYJHZX-2-201719，“久病入络”理论指导选方配穴治疗腰突症的临床研究，2017-12至2019-12，10万元。 5.国家自然科学基金委员会，面上项目，81571828，调控3D打印水凝胶的理化特征促进间充质干细胞的成骨分化及其在骨修复中的应用，2016-01至2019-12，55万元，已结题，主持。 6.上海市科委研究项目，14411963700，3D打印技术构建的新型复合组织工程骨治疗脊柱肿瘤切除术后骨缺损的研究，2014-08至2017-09，20万，已结题，主持。 7.上海市卫生局科研课题，20114022，利福平缓释载药组织工程骨的实验研究，2012-01至2013-12，10万元，已结题，主持。 8.国家自然科学基金委员会，面上项目，30970735，转基因骨髓间充质干细胞与自体血小板凝胶生物支架构建组织工程骨的实验研究，2010-01至2012-12，30万，已结题，主持。 9.上海市科技委员会科研计划项目，09ZR1410200，转基因BMSCs复合PRP凝胶构建组织工程骨， 2009-06至2011-06，10万，已结题，主持。
*获得专利 一种组织工程骨及其制备方法和应用方法，专利号：ZL201910275768.2 发文日：2020.6.2 一种单侧椎板入路手术用牵开器，专利号：ZL201920848583.1 发文日：2020.6.16
*科研奖项 2017年上海市科技进步，一等奖，脊柱肿瘤的发生机制及治疗新策略的相关研究，排名9
*发表SCI论文 CheL, Wang Y, Sha D, Li G, Wei Z, Liu C, Yuan Y, SongD*.A biomimetic and bioactive scaffold with intelligently pulsatileteriparatide delivery for local and systemic osteoporosisregeneration. Bioact Mater. 2022 Apr 5;19:75-87. （通讯作者） TanX, Tong L, Li L, Xu J, Xie S, Ji L, Fu J, Liu Q, Shen S, Liu Y,Xiao Y, Gao F, Moses RE, Bardeesy N, Wang Y, Zhang J, Tang L, LiL, Wong KK, SongD*,Yang X*, Liu J*, Li X*. Loss of Smad4 promotes aggressive lungcancer metastasis by depression pf PAK3 via miRNA regulation.Nature Communications. Nat Commun. 2021 Aug 11;12(1):4853. IF=14.919（共同通讯作者） YangYan, Lei Zhou, Zhengwang Sun*, DianwenSong*,Yiyun Cheng*. Targeted and intracellular delivery of proteintherapeutics by a boronated polymer for the treatment of bonetumors. Bioactive Materials. 2021.https://doi.org/10.1016/j.bioactmat.2021.05.041. IF=14.593（共同通讯作者） MengT, Huang R, Jin J, Gao J, Liu F, Wei Z, Xu X, Chang Z, Lin J, TaN, Huang Z, Yin H*, Zhou W*, SongD*.The comparative integrated multi-omics analysis identifies CA2 asa novel target for chordoma. Neuro Oncol. 2021 Jul 2:noab156. IF=12.3（通讯作者） HuJ, Zhang C, Zhou L, Hu Q, Kong Y, SongD*,Cheng Y* and Zhang Y*.A smart hydrogel for on-demand delivery ofantibiotics and efficient eradication of biofilms. Sci. ChinaMater. 2021, 64 (4):1035-1046. IF=8.273 (共同通讯) MengT, Huang R, Hu P, Yin H, Lin S, Qiao S, Wang R, Wang J, Cai Z,Huang Z*, Cheng L*, SongD*. NovelNomograms as Aids for Predicting Recurrence and Survival inChordoma Patients: A Retrospective Multicenter Study in mainlandChina. Spine (Phila Pa 1976). 2021 Jan 1;46(1):E37-E47. Q2 IF=3.468 (通讯作者) ChenJ, Miao W, Yang S, Yin M, Zhao J* and SongD*.LncRNA NR_027471 Functions as a ceRNA for miRNA-8055 Leading toSuppression of Osteosarcoma by Regulating the Expression ofTP53INP1. Front Oncol. 2020, Sep 10:563255. IF=6.244（通讯作者） ChenJ, Yang S, Wu C, Cui Z, Wan Y, Xu G, Bao G, Zhang J, Chen C, SongD*.Novel Role of HAX-1 in Neurons Protection After Spinal CordInjury Involvement of IRE-1. Neurochem Res. 2020Oct;45(10):2302-2311. IF= 3.038（通讯作者） MaoM, Zhou L, Huang C, Yan X, Hu S, Yin H, Zhao Q and SongD*.A Malignant Liver and Thoracic Solitary Fibrous Tumor: A 10-YearJourney From the Brain to the Liver and the Spine. Front.Surg. 7:570582. doi: 10.3389/fsurg. 2020.570582 IF=2.718（通讯作者） CheL, Lei Z, Wu P*, SongD*.A 3D Printable and Bioactive Hydrogel Scaffold to Treat TraumaticBrain Injury. Advanced Functional Materials, 2019; 29(39):1904450. IF= 16.836（通讯作者） MengT, Jin J, Jiang C, Huang R, Yin H*,Song D*,Cheng L*. Molecular Targeted Therapy in the Treatment ofChordoma: A Systematic Review. Front Oncol. 2019 Feb 1;9:30.IF=4.843(通讯作者) HuangR, Meng T, Chen R, Yan P, Zhang J, Hu P, Zhu X, Yin H*, SongD*,Huang Z*. The Construction and Analysis of Tumor-infiltratingImmune Cell and ceRNA Networks in Recurrent Soft Tissue Sarcoma.Aging (Albany NY). 2019 Nov 18; 11(22):10116-10143.IF=4.831（通讯作者） MengT, Huang R, Zeng Z, Huang Z, Yin H, Jiao C, Yan P, Hu P, Zhu X,Li Z, SongD*,Zhang J*, Cheng L*. Identification of prognostic and metastaticalternative splicing signatures in kidney renal clear cellcarcinoma. Frontiers in biomedicine and biotechnology.2019;7:270. IF=3.644（通讯作者） MiaoW, Chen J, Jia L, Ma J*, SongD*.The m6A methyltransferase METTL3 promotes osteosarcomaprogression by regulating the m6A level of LEF1. Biochem BiophysRes Commun. 2019 Aug 27;516(3):719-725. IF=2.705（通讯作者） YangH, Wan Z, Huang C, Yin H*, SongD*.AMPH-1 is a tumor suppressor of lung cancer by inhibitingRas-Raf-MEK-ERK signal pathway. Lasers Med Sci. 2019Apr;34(3):473-478. IF=1.949（第一作者） WanW, Yang C, Yan W, Liu T, Yang X, SongD*, Xiao J*.Adult-onset intradural spinal teratoma: report of 18 consecutivecases and outcomes in a single center. Eur Spine J.2017;26(7):1917-1928. IF=2.563（通讯作者） YinH, Meng T, Shu L, Mao M, Zhou L, Chen H, SongD*. Novelreduction-sensitive micellar nanoparticles assembled fromRituximab-doxorubicin conjugates as smart and intuitive drugdelivery systems for the treatment of non-Hodgkin's lymphoma.Chem Biol Drug Des. 2017 Nov;90(5):892-899. IF=2.396 （通讯作者） LuY, Ning H, Jiang X, Yang R, SongD*,Yuan H*. Metabolomics reveals hippocampal metabolic fluctuationsof postoperative fatigue syndrome and anti-fatigue effect ofCarthamus tinctorius L extract in rat model. BiomedChromatogr.2017 Jul;30(7):1052-1058. IF=1.723 (通讯作者) SongD#,Meng T#, Lin Z#, Fan T, Li B, Yin H, Li Z, et al: ClinicalFeatures and Prognostic Factors of Pediatric Spine Tumors: ASingle-Center Experience with 190 Cases. Spine (Phila Pa 1976)2016. 41(12):1006-12. IF=2.439（第一作者） HuangQ, Wei H, Wu Z, Li L, Yao L, Sun Z, Li L, Lin Z, Xu W, Han S, CaoW, Xu Y, SongD*,Yang X*, Xiao J*. PreferentiallyExpressed Antigen of Melanoma Prevents Lung Cancer Metastasis.PLoS One. 2016;11(7):e0149640. IF=3.057 (通讯作者) SunZ, Wu Z, Zhang F, Guo Q, Li L, Li K, Chen H, Zhao J, SongD*, Huang Q*, LiL*, Xiao J*. PRAME is critical for breast cancer growth andmetastasis. Gene. 2016. 594(1):160-164. IF=2.319（通讯作者） MengT, Chen R, Zhong N, Fan T, Li B, Yin H, Li Z, Zhou W, SongD*,Xiao J*. Factors associated with improved survival followingsurgical treatment for metastatic prostate cancer in the spine:retrospective analysis of 29 patients in a single center. World JSurg Oncol. 2016;14(1):200. IF=1.286（通讯作者） YangJ, Yang X, Miao W, Jia Q, Wan W, Meng T, Wu Z, Cai X, SongD*,Xiao J*. Spine extra-osseous chordoma mimickingneurogenic tumors: report of three cases and review of theliteratures. World J Surg Oncol. 2016;14(1):206. IF=1.286（通讯作者） SongD#,Meng T#, Xu W#, Hou T, Lin Z, Yin H, Li B, Zhou L, et al:5-Fluoruracil blocked giant cell tumor progression by suppressingosteoclastogenesis through NF-kappaB signals and blockingangiogenesis. Bone 2015, 78:46-54. IF= 3.736（第一作者） MengT, Yin H, Li B, Li Z, Xu W, Zhou W, Cheng M, Wang J, Zhou L, YangX, SongD*,Xiao J: Clinical features and prognostic factors of patients withchordoma in the spine: a retrospective analysis of 153 patientsin a single center. Neuro Oncol 2015, 17:725-732.IF=7.371（通讯作者） MengT, Yin H, Li Z, Li B, Zhou W, Wang J, Zhou L, SongD*,Xiao J: Therapeutic strategy and outcome of spine tumors inpregnancy: a report of 21 cases and literature review. Spine(Phila Pa 1976) 2015, 40:E146-153. IF=2.439（通讯作者） MengT, Zhou W, Li B, Yin H, Li Z, Zhou L, Kong J, Yan W, Yang X, LiuT, SongD*,Xiao J*: En bloc resection for treatment of tumor-inducedosteomalacia: a case presentation and a systematic review. WorldJ Surg Oncol 2015, 13:176. IF=1.286（通讯作者） ChenC, Chen Q, Ouyang Q, Sun J, Liu F, SongD*,Yuan H*. Transient early neurotrophin release and delayedinflammatory cytokine release by microglia in response to PAR-2stimulation. Journal of Neuroinflammation. 2012,9:142. IF=4.351(通讯作者)
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