三、主要科研工作与成绩 主持或参加科研项目: 国防科技项目管理中心，基础加强计划技术领域基金项目，2019-JCJQ-JJ-066，基于氧化石墨烯的抗蓖麻毒素核酸适配体纳米阵列，2020-01至2021-12，50万元，在研，主持 海军军医大学，“远航”军事医学人才类项目，2019-YH-09，岛礁疾病谱样本保藏策略及信息化建设研究，2020-01至2021-12，20万元，在研，主持 国家自然科学基金委员会，重点项目，81730076，hsa_circ_RPPH1/ hsa_circ_00 03596调控循环肿瘤干细胞间充质-上皮转化促进肝癌转移的机制研究，2018-01至2022-12，290万元，在研，参与 中国博士后科学基金面上资助，LOC101929219在卵巢癌转移中的作用机制研究，2017-06至2019-06，结题，主持 国家自然科学基金委员会，青年项目，31400778，磷酸酶PTEN在巨噬细胞介导的抗隐球菌固有免疫反应中的作用机制研究，2015-01至2017-12，25万元，结题，主持
发表论著： LiangChen#, Ruijiao Kong#,Cong Wu, ShuoWang, Zixin Liu, Shupeng Liu, Shuiping Li, Tian Chen, ChuanbinMao*, and Shanrong Liu*. Circ-MALAT1 Functions as Both an mRNATranslation Brake and a microRNA Sponge to Promote Self-Renewalof Hepatocellular Cancer Stem Cells. Adv Sci (Weinh) 2020, 7(4):1900949. HuiminMa# , Meng Yu# , CongWu, Houbao Huang,Yawei Li, Peng Zhang, Jianjun Huang, Long Cheng, Gang Feng* ,Guorong Li, Overexpression of Spondin-2 Is Associated withRecurrence-Free Survival in Patients with Localized Clear CellRenal Cell Carcinoma, Disease Markers, 2020; 2020(88):5074239. CongWu#,Wei Wan#,Ji Zhu, Hai Jin, Tiejun Zhao*,Huafei Li*,Induction of potent apoptosis by an anti-CD20 aptamer via thecrosslink of membrane CD20 on non-Hodgkin’s lymphoma cells, RSCAdvances, 2017, 7:5158-5166. Hua-FeiLi#,*,Cong Wu#,Ting Chen#,Ge Zhang, He Zhao, Chang-Hong Ke, Zheng Xu*,Construction and characterization of an anti-CD20 mAb nanocombwith exceptionally excellent lymphoma-suppressing activity,International Journal of Nanomedicine, 2015, 10:4783-96. HuafeiLi#,Cong Wu#,Mao Xia#,He Zhao, Mengxin Zhao, Jin Hou, Rong Li, Lixin Wei*,Li Zhang*,Targeted and controlled drug delivery using a temperature andultra-violet responsive liposome with excellent breast cancersuppressing ability, RSC Advances, 2015, 5(35):27630-39. HuafeiLi#,Kun Guo#,Cong Wu#,Ling Shu, Shiwei Guo, Jing Hou, Naping Zhao, Lixin Wei, XiaoboMan, Li Zhang*,Controlled and Targeted Drug Delivery by a UV-responsive Liposomefor Overcoming Chemo-resistance in Non- Hodgkin Lymphoma, ChemBiol Drug Des, 2015, 86(4):783-94. CongWu#,Huafei Li#,*,He Zhao#,Weiwei Zhang, Yan Chen, Zhanyi Yue, Qiong Lu, Yuxiang Wan, XiaoxuTian, Anmei Deng*.Potentiating antilymphoma efficacy of chemotherapy using aliposome for integration of CD20 targeting, ultra-violetirradiation polymerizing, and controlled drug delivery, NanoscaleRes Lett, 2014, 9(1): 447. 3.17 CongWu#,Yiquan Xue#,Pin Wang#,Li Lin, Qiuyan Liu, Nan Li, Junfang Xu, Xuetao Cao*.IFN-gamma primes macrophage activation by increasing phosphataseand tensin homolog via downregulation of miR-3473b, J Immunol,2014, 193(6): 3036-3044. CongWu#,Yi Zhang#,Yingming Jiang, Quanxing Wang, Yao Long, Chunmei Wang, XuetaoCao*,Guoyou Chen*,Apoptotic cell administration enhances pancreatic isletengraftment by induction of regulatory T cells and tolerogenicdendritic cells, Cell Mol Immunol, 2013, 10(5): 393-402. PinWang, Yiquan Xue, Yanmei Han, Li Lin, CongWu, Sheng Xu,Zhengping Jiang, Junfang Xu, Qiuyan Liu, Xuetao Cao*,The STAT3-binding long noncoding RNA lnc-DC controls humandendritic cell differentiation, Science,2014, 344(6181):310-313. PinWang#,Yan Gu#,Qian Zhang#,Yanmei Han, Jin Hou, Li Lin, CongWu, Yan Bao,Xiaoping Su, Minghong Jiang, Qingqing Wang, Nan Li, Xuetao Cao*,Identification of resting and type I IFN-activated human NK cellmiRNomes reveals microRNA-378 and microRNA-30e as negativeregulators of NK cell cytotoxicity, J Immunol, 2012,189(1):211-221. 李林林,吴聪*.长链非编码RNA在自身免疫性疾病中的研究进展[J].基础医学与临床,2019,39(4):573-576. 吴聪,方超萍,俞靖龙,刘善荣*.精准医学给予检验医学的机遇与挑战[J].中华检验医学杂志,2017, 40(01):14-16.
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