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论文 Wang X, Teh CSC, IshizawaT, Aoki T, Cavallucci D, Lee SY, Panganiban KM, Perini MV, ShahSR, Wang H, Xu Y, Suh KS, Kokudo N. Consensus Guidelines for theUse of Fluorescence Imaging in Hepatobiliary Surgery. AnnSurg. 2021 Jul 1;274(1):97-106. doi:10.1097/SLA.0000000000004718. (第一及通讯作者)IF=12.96 ZhuK,Wang W, Luo R, Song D, Wang X, Gao Q, Fan J, Zhou J, Rao S, WangX. Newly detected liver noduleswith a history of colorectal cancer: are they metastatic? Reviewof 2,632 cases in a single center. AnnTransl Med. 2021 Jul;9(13):1079. (通讯作者)IF=3.932 SongD, Wang Y, Wang W, Wang Y, Cai J, Zhu K, Lv M, Gao Q, Zhou J, FanJ, Rao S, Wang M, Wang X.Using deep learning to predict microvascular invasion inhepatocellular carcinoma based on dynamic contrast-enhanced MRIcombined with clinical parameters. JCancer Res Clin Oncol. 2021Dec;147(12):3757-3767. doi: 10.1007/s00432-021-03617-3. (通讯作者)IF=4.553 Tian L, Ma J, Ma L, Zheng B, Liu L, Song D, Wang Y,Zhang Z, Gao Q, Song K, WangX*. PD-1/PD-L1 expression profileswithin intrahepatic cholangiocarcinoma predict clinical outcome.World J Surg Oncol.2020 Nov 23;18(1):303. doi: 10.1186/s12957-020-02082-5.(通讯作者)IF=2.754 Song D, Wang Y, Zhu K, Tian L, Gao Q, Zhou J, FanJ, Wang X*.DCK is a promising prognostic biomarker and correlated withimmune infiltrates in hepatocellular carcinoma. WorldJ Surg Oncol. 2020 Jul 20;18(1):176. doi:10.1186/s12957-020-01953-1. (通讯作者)IF=2.754 Fu XT, Tang Z, Chen JF, Shi YH, Liu WR, Gao Q, DingGY, Song K, Wang XY*,Zhou J, Fan J*, Ding ZB*. Laparoscopic hepatectomy enhancesrecovery for small hepatocellular carcinoma with liver cirrhosisby postoperative inflammatory response attenuation: a propensityscore matching analysis with a conventional open approach. SurgEndosc. 2020 Aug 3. doi:10.1007/s00464-02007710-5. Epub ahead of print. PMID: 32748270.(通讯作者)IF=4.584 Liu LZ, Zhang Z, Zheng BH, Shi Y, Duan M, Ma LJ,Wang ZC, Dong LQ, Dong PP, Shi JY, Zhang S, Ding ZB, Ke AW, CaoY, Zhang XM, Xi R, Zhou J, Fan J, WangXY*, Gao Q*. CCL15 recruitssuppressive monocytes to facilitate immune escape and diseaseprogression in hepatocellular carcinoma. Hepatology.2019 Jan;69(1):143-159. doi: 10.1002. (通讯作者)IF=17.425 Zheng BH, Liu LZ, Zhang ZZ, Shi JY, Dong LQ, TianLY, Ding ZB, Ji Y, Rao SX, Zhou J, Fan J, WangXY*, Gao Q*. Radiomics Score: APotential Prognostic Imaging Feature for Postoperative Survivalof Solitary HCC Patients. BMCCancer. 2018Nov 21;18(1):1148. (通讯作者)IF=4.430 Ma LJ, Feng FL, Dong LQ, Zhang Z, Duan M, Liu LZ,Shi JY, Yang LX, Wang ZC, Zhang S, Ding ZB, Ke AW, Cao Y, ZhangXM, Zhou J, Fan J, Wang XY*,Gao Q*. Clinical Significance of PD-1/PD-Ls Gene Amplificationand Overexpression in Patients with Hepatocellular Carcinoma.Theranostics. 2018Nov 10;8(20):5690-5702. (通讯作者)IF=11.556 LiuLZ, Yang LX, Zheng BH, Dong PP, Liu XY, Wang ZC, Zhou J, Fan J,Wang XY*,Gao Q*. CK7/CK19 index: A potential prognostic factor forpostoperative intrahepatic cholangiocarcinoma patients. JSurg Oncol. 2018 Jun;117(7):1531-1539(通讯作者)IF=3.454 ShiJY, Ma LJ, Zhang JW, Duan M, Ding ZB, Yang LX, Cao Y, Zhou J, FanJ, Zhang X, Zhao YJ, WangXY*,Gao Q*. FOXP3 Is a HCC suppressor gene and Acts throughregulating the TGF-β/Smad2/3 signaling pathway. BMCCancer.2017 Sep 13;17(1):648. (通讯作者)IF=4.430 MaLJ#, WangXY#,Duan M#, Liu LZ, Shi JY, Dong LQ, Yang LX, Wang ZC, Ding ZB, KeAW, Cao Y, Zhang XM, Zhou J, Fan J, Gao Q. Telomere lengthvariation in tumor cells and cancer-associated fibroblasts:potential biomarker for hepatocellular carcinoma. JPathol.2017 Dec;243(4):407-417. doi: 10.1002 2017 Oct 13. PMID:28833123; (第一作者)IF=7.996 ShiJY, Duan M, Sun QM, Yang L, Wang ZC, Mynbaev OA, He YF, Wang LY,Zhou J, Tang QQ, Cao Y, Fan J, WangXY*,Gao Q*. Naive Treg-like CCR7(+) mononuclear cells indicateunfavorable prognosis in hepatocellular carcinoma. Tumour Biol.2016;37(7):9909-17.(通讯作者) LiuLZ, He YZ, Dong PP, Ma LJ, Wang ZC, Liu XY, Duan M, Yang LX, ShiJY, Zhou J, Fan J, Gao Q, WangXY*.Protein tyrosine phosphatase PTP4A1 promotes proliferation andepithelial-mesenchymal transition in intrahepaticcholangiocarcinoma via the PI3K/AKT pathway. Oncotarget.2016.7(46)75210(通讯作者)IF=5.008 MaL, Dong P, Liu L, Gao Q, Duan M, Zhang S, Chen S, Xue R*, WangX*.Overexpression of proteinO-fucosyltransferase 1 accelerates hepatocellular carcinomaprogression via the Notch signaling pathway. Biochem Biophys ResCommun. 2016 Apr 29;473(2):503-10 (Correspondingauthor)IF=2.466 XuJM#, Wei Y#, Wang XY#,Fan H, Chang WJ, Ren L, Jiang W, Fan J, Qin XY. Robot-assistedone-stage resection of rectal cancer with liver and lungmetastases. World J Gastroenterol. 2015 Mar 7;21(9):2848-53. doi:10.3748/wjg.v21.i9.2848. PMID: 25759560; PMCID: PMC4351242.(第一作者) SongFN, Duan M, Liu LZ, Wang ZC, Shi JY, Yang LX, Zhou J, Fan J, GaoQ, Wang XY*. RANKLpromotes migration and invasion of hepatocellular carcinoma cellsvia NF-κB-mediated epithelial-mesenchymal transition. PLoS One.2014 Sep 30;9(9):e108507. doi: 10.1371/journal.pone.0108507.eCollection 2014. (Corresponding author)IF=2.766 DuanM#, Wang ZC#, Wang XY#,Shi JY, Yang LX, Ding ZB, Gao Q, Zhou J, Fan J. TREM-1, anInflammatory Modulator, is Expressed in Hepatocellular CarcinomaCells and Significantly Promotes Tumor Progression. Ann SurgOncol. 2014 Dec 3. [Epub ahead of print](Joint first author) GaoQ#, Zhao YJ#, Wang XY#,Guo WJ, Gao S, Wei L, Shi JY, Shi GM, Wang ZC, Zhang YN, Shi YH,Ding J, Ding ZB, Ke AW, Dai Z, Wu FZ, Wang H, Qiu ZP, Chen ZA,Zhang ZF, Qiu SJ, Zhou J, He XH, Fan J. Activating mutations inPTPN3 promote cholangiocarcinoma cell proliferation and migrationand are associated with tumor recurrence in patients.Gastroenterology. 2014 May;146(5):1397-407. doi:10.1053/j.gastro.2014.01.062. Epub 2014 Feb 4. (Jointfirst author) GaoQ#, Zhao YJ#, Wang XY#,Qiu SJ, Shi YH, Sun J, Yi Y, Shi JY, Shi GM, Ding ZB, Xiao YS,Zhao ZH, Zhou J, He XH, Fan J. CXCR6upregulation contributes to a proinflammatory tumormicroenvironment that drives metastasis and poor patient outcomesin hepatocellular carcinoma. Cancer Res. 2012 Jul15;72(14):3546-56. doi: 10.1158/0008-5472. (Jointfirst author) GaoQ#, Zhou J#, Wang XY#,Qiu SJ, Song K, Huang XW, Sun J, Shi YH, Li BZ, Xiao YS, Fan J.Infiltratingmemory/senescent T cell ratio predicts extrahepatic metastasis ofhepatocellular carcinoma. Ann Surg Oncol. 2012Feb;19(2):455-66. doi: 10.1245/s10434-011-1864-3. (Jointfirst author) GaoQ#, Wang XY#, QiuSJ, Zhou J, Shi YH, Zhang BH, Fan J. Tumorstroma reaction-related gene signature predicts clinical outcomein human hepatocellular carcinoma. Cancer Sci. 2011Aug;102(8):1522-31. Epub 2011 Jun 9. (Jointfirst author) ZhaoYJ#, Wang XY#,Wang T, Hu X, Hui X, Yan M, Gao Q, Chen TY, Li JJ, Yao M, Wan DF,Gu J, Fan J, He XH. Acetylcholinesterase, a key prognosticpredictor for hepatocellular carcinoma, suppresses cell growthand induces chemosensitization. Hepatology. 2011Feb;53(2):493-503. (Joint first author) GaoQ#, Wang XY#, QiuSJ, Yamato I, Sho M, Nakajima Y, Zhou J, Li BZ, Shi YH, Xiao YS,Xu Y, Fan J. Overexpressionof PD-L1 significantly associates with tumor aggressiveness andpostoperative recurrence in human hepatocellular carcinoma.Clin Cancer Res. 2009 Feb 1;15(3):971-9.(Joint first author) GaoQ#, Wang XY#, FanJ, Qiu SJ, Zhou J, Shi YH, Xiao YS, Xu Y, Huang XW, Sun J.Selection of reference genes for real-time PCR in humanhepatocellular carcinoma tissues. J Cancer Res Clin Oncol. 2008Sep;134(9):979-86. (Joint first author).
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