三、主要科研工作与成绩 近3年作为第一负责人承担的横向科研项目:
国家自然科学基金面上项目,RIPK-1调控血管壁中性粒细胞诱捕网介导聚乳酸可吸收支架内血栓形成的机制研究,项目负责人,2022.01-2025.12 中国医学科学院公益基金,基于冷冻消融系统的去交感神经器械治疗心血管疾病的研发和应用,项目负责人,2021.01-2021.12 上海市临床三年行动计划重大临床研究项目,应用造影-光学相关断层扫描融合技术精确引导生物可吸收冠脉支架植入的中长期预后的影响,项目负责人,2020.10-2022.09 科技部国家重点研发计划,基于多模态影像和3D打印技术的新型血管内植入物研发,子课题负责人,2020.01-2021.12 上海市卫健委,上海市“医苑新星”青年医学人才资助计划,项目负责人,2019.01-2021.12
近3年代表性论文:
Wang R, Lu J, Yin J, Chen H, Liu H, Xu F, Zang T,Xu R, Li C, Wu Y, Wu Q, Fei X, Zhu M, Shen L, Ge J. A TEMPOL andrapamycin loaded nanofiber-covered stent favorsendothelialization and mitigates neointimal hyperplasia andlocal inflammation. Bioact Mater. 2022 May 11;19:666-677.(通讯作者) Zang T, Chen H, Shen S, Xu F, Wang R, Yin J, ChenX, Guan M, Shen L, Pan H, Ge J. Highly Purified EicosapentaenoicAcid Alleviates the Inflammatory Response and Oxidative Stressin Macrophages during Atherosclerosis via themiR-1a-3p/sFRP1/Wnt/PCP-JNK Pathway. Oxid Med Cell Longev. 2022Apr 13;2022:9451058.(通讯作者) Ji M, Chen H, Shen L, Zhang Y, Yao Z, Wu Y, Xu Y,Ge J. Validation of a Novel Renal Denervation System WithCryoablation: A Preclinical Study and Case Series. JACC BasicTransl Sci. 2022 Feb 2;7(2):101-112.(共同第一作者) Ma Q, Shi X, Tan X, Wang R, Xiong K, Maitz MF, CuiY, Hu Z, Tu Q, Huang N, Shen L, Yang Z. Durableendothelium-mimicking coating for surface bioengineeringcardiovascular stents. Bioact Mater. 2021 May24;6(12):4786-4800.(通讯作者) Chen H, Wang R, Li Q, Yin J, Ge Z, Xu F, Zang T,Pei Z, Li C, Shen L, Ge J. Immediate Renal Denervation AfterAcute Myocardial Infarction Mitigates the Progression of HeartFailure via the Modulation of IL-33/ST2 Signaling. FrontCardiovasc Med. 2021 Oct 1;8:746934. doi:10.3389/fcvm.2021.746934.(通讯作者) Xu F, Shen L, Chen H, Wang R, Zang T, Qian J, Ge J.circDENND1B Participates in the Antiatherosclerotic Effect ofIL-1β Monoclonal Antibody in Mouse by Promoting CholesterolEfflux via miR-17-5p/Abca1 Axis. Front Cell Dev Biol. 2021 Apr29;9:652032.(通讯作者) Chen S, Yao Z, Guan Y, Yang H, Shahzad MB, Wu Y,Zhang B, Shen L, Yang K. High nitrogen stainless steeldrug-eluting stent - Assessment of pharmacokinetics andpreclinical safety in vivo. Bioact Mater. 2020 Jun21;5(4):779-786.(通讯作者) Lu, J., Wang, R., Shen, L., Yin, J., Liu, G., Chen,H., Xu F., Wu Q., Ye C., Fei X., Ge J., Zhu, M. Enabling topicaland long-term anti-radical properties for percutaneous coronaryintervention-related complications by incorporating TEMPOL intoelectrospun nanofibers. Science China Materials, 2020 Oct 64(3),769-782.(共同第一作者)
近3年发表专著:
《介入心脏病学—Braunwald心脏病学姊妹卷》北京大学医学出版社(副主编) 授权专利
镁合金血管支架,201520261612.6(实用新型,排名3) 高压低温流体泵,201710201355.0(发明专利,排名4) 一种封堵器,201720115325.3(实用新型,排名5) 一种血流分流器,201610864657.1(发明专利,排名2) 镁合金支架的处理液及处理方法,201510127404.1(发明专利,排名3) 桡动脉止血器,201220645752.X(实用新型,排名2) 一种可完全回收和重复释放的生物腔体锚定装置,201720698691.6(实用新型,排名5)
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