董智慧-硕博士研究生指导教师

发布者:于小青发布时间:2022-06-16浏览次数:1220


姓名

董智慧


职称

主任医师

导师资格

博导

学科专业

血管外科

联系方式

E-maildzh926@126.com

一、个人简介

董智慧,复旦大学附属中山医院血管外科党支部书记、科室副主任、主任医师、博士生导师。现任复旦大学附属中山医院血管外科副主任,中华医学会医学工程分会干细胞工程专业委员会委员,上海市医学会血管外科分会委员兼秘书,上海普外临床质控中心血管外科专家组委员兼秘书。上海市优秀学术带头人,上海市卫生计生系统优秀学科带头人。近年来,作为导师培养硕士研究生6名,博士5名。副主编专著2部,副主译专著3部,参编专著2部。每年培训进修及主持规培医生约2000人次,年均专家门诊量5000-6000人次,年均主刀手术700-800台,其中>50%为四级手术。主持国自然课题5项,3项省部级课题及5项上海市、1项美国血管外科学会、1项复旦大学和2项中山医院人才基金。

国际上首次提出“支架源性主动脉损伤”理论,以第一作者发表于期刊《Circulation》和《JVasc Surg》。

采用自体干细胞移植治疗血栓闭塞性脉管炎等肢体重度缺血,使青壮年患者踝上截肢率由31%降低至8.8%,劳动力丧失率由34.8%降至18.7%5年有效率88%,相关成果作为通讯/第一作者分别发表于《Lancet》子刊《EBioMedicine》,《JVasc Surg》(封面论著),《StemCells TranslMed》(特色论著)等相关领域权威期刊。荣获教育部科技进步二等奖(2次)、华夏医学科技奖一等奖、上海市科技进步二、三等奖、中华医学科技奖二等奖和上海医学科技奖一等奖。

二、主要学习与工作经历

学习经历:

20009-20037月  南通医学院普外科,硕士研究生

20039-20067月  复旦大学附属中山医院血管外科,博士研究生

工作经历:

20067

20076月       复旦大学附属中山医院血管外科   住院医师

20077

201211月      复旦大学附属中山医院血管外科   主治医师

201212月-201711月     复旦大学附属中山医院血管外科   副主任医师

2014年-至今                 复旦大学附属中山医院血管外科  副教授;硕导

2017-12-至今               复旦大学附属中山医院血管外科  主任医师

2019-03-至今               复旦大学附属中山医院血管外科   博导

2019-05-至今               复旦大学附属中山医院血管外科  科室副主任

2020-04-至今                复旦大学附属金山医院血管与创面中心主任

2020-06至今                复旦大学附属中山医院,血管外科党支部书记

三、主要科研工作与成绩

科研项目

1.2021国家放射与治疗临床医学研究中心临床研究重点项目(2021-006):准分子激光消蚀糖尿病足血运重建的前瞻性、多中心、随机对照临床研究,60万元,在研,主持

2.上海市科委(上海市2021年度“科技创新行动计划”医学创新研究专项项目),国家创新医疗器械复合疝修补补片诱导皮肤缺损再生修复的多中心真实世界研究,编号21Y11911800,资助60万,2021/10/01-2024/09/30

3.2021年度复旦大学“临床名医培育工程”,编号2021MYPY00270万元,在研,主持(人才计划)

4.国家自然科学基金委员会,面上项目,81970407LRG1在干细胞移植治疗炎性重度肢体缺血中的作用及机制研究,2020-012023-1255万元,在研,主持

5.复旦大学“明日之星”名医培育工程,无编号,2019-052021-0420万元,在研,主持(人才计划)

6.上海市优秀学术带头人,19XD14012002019202240万元,在研,主持(人才计划)

7.国家自然科学基金委员会,面上项目,81981330066,“国际(地区)合作与交流项目-面向临床的4D-PC-MRI主动脉夹层血流动力学研究”双边研讨会,2019-012019-1214.9万元,已结题,主持

8.上海市卫生计生系统优秀学科带头人培养计划(百人计划),2018BR402018-072021-0645万元,已结题,主持(人才计划)

9.国家自然科学基金委员会,面上项目,81770508,基于4D-PC-MRI的主动脉夹层TEVAR术后血流-支架-主动脉间耦合作用的仿真研究,2018-012021-1255万元,已结题,主持

10.InternationalExchange Scheme-Cost Share Program (2016) between Royal Society(UK) and NSFC (China)IE161052acomputational framework for false lumen thrombosis in type Baortic dissection2017-032019-021.2万英镑,已结题,中方负责人

代表论文

1.ChenPeng#; Lingwei Zou#; Kai Hou#; Yifan Liu; Xiaolang Jiang; WeiguoFu; Yang Yang; Benyebka Bou-Said; Shengzhang Wang*; Zhihui Dong*;Material parameter identification of the proximal and distalsegments of the porcine thoracic aorta based on ECG-gated CTangiography; Journal of Biomechanics; 2022; 138:111106

2.YifanLiu#; Lingwei Zou#; Hanfei Tang; Jie Li; Hao Liu; Xiaolang Jiang;Baohong Jiang*; Zhihui Dong*; Weiguo Fu*; Single-Cell Sequencingof Immune Cells in Human Aortic Dissection Tissue ProvidesInsights Into Immune Cell Heterogeneity, Frontiers inCardiovascular Medicine, 2022;9:791875

3.YifanLiu#; Xiaolang Jiang#; Bin Chen; Junhao Jiang; Tao Ma; ZhihuiDong*; Weiguo Fu; Risk factors and treatment outcomes for type Baortic dissection with malperfusion requiring adjunctiveprocedures after thoracic endovascular aortic repair, Journal ofVascular Surgery, 2022, 75(4), 1192-1200

4.TaoMa#, Min Zhou#, Zhuang Yuan Meng#, Shengzhang Wang*, Zhi HuiDong*, Wei Guo Fu*. Computational Investigation andHistopathological Validation of Interaction Between Stent Graftand Aorta in Retrograde Type A Dissection After TEVAR in CanineModels. Journal of Endovascular Therapy, 2022;29(2):275-282.

5.TianyuePan#, Xiaolang Jiang#, Hao Liu, Yifan Liu, Weiguo Fu*, ZhihuiDong*. Prediction of 2-year major adverse limb event-free survivalafter percutaneous transluminal angioplasty and stenting for lowerlimb atherosclerosis obliterans: a machine learning-based study.Front Cardiovasc Med. 2022 Feb 9.

6.HaoLiu#, Yifan Liu#, Tianyue Pan, Yuan Fang, Gang Fang, XiaolangJiang, Bin Chen, Zheng Wei, Shiyang Gu, Peng Liu, Weiguo Fu*,Zhihui Dong*. Return to work after cell transplantation inpatients with angiitis-induced critical limb ischaemia and factorsrelated: a single-centre retrospective cohort study. Stem Cell ResTher, 2022, 13(1), 139.

7.HaoLiu#, Tianyue Pan#, Yifan Liu, Yuan Fang, Gang Fang, XiaolangJiang, Bin Chen, Zheng Wei, Shiyang Gu, Peng Liu, Weiguo Fu*,Zhihui Dong*. The peripheral blood mononuclear cells versuspurified CD34 cells transplantation in patients withangiitis-induced critical limb ischemia trial: 5-year outcomes andreturn to work analysis-a randomized single-blindednon-inferiority trial. Stem Cell Res Ther, 2022, 13: 116.

8.JiangX#, Liu Y#, Chen B, Jiang J, Shi Y, Ma T, Lin C, Guo D, Xu X, FuW*, Dong Z*. Clinical features and outcomes after endovasculartherapy for penetrating aortic ulcer and intramural hematoma.Vascular, 2022;30(2):191-198.

9.XiaoxinKan#, Tao Ma#, Jing Lin, Lu Wang, Zhihui Dong*, Xiao Yun Xu*.Patient-specific simulation of stent-graft deployment in type Baortic dissection: model development and validation. Biomechanicsand modeling in mechanobiology, 2021;20(6):2247-2258.

10.TaoMa#, Fei Liu#, Bin Chen, Jun Hao Jiang, Yun Shi, Da Qiao Guo, XinXu, Zhi Hui Dong*, Wei Guo Fu*. Intraoperative Stent-Graft-InducedAortic Intimal Intussusception During TEVAR for Type B AorticDissection. Journal of Endovascular Therapy, 2021;28(6):860-870.

11.HaoLiu#, Tianyue Pan#, Yuan Fang, Gang Fang, Yifan Liu, XiaolangJiang, Bin Chen, Zheng Wei, Shiyang Gu, Peng Liu, Weiguo Fu*,Zhihui Dong*. Three-year outcomes of peripheral blood mononuclearcells vs purified CD34 cells in the treatment of angiitis-inducedno-option critical limb ischemia and a cost-effectivenessassessment: A randomized single-blinded noninferiority trial. StemCells Transl Med, 2021, 10(5), 647-659.

12.XiaolangJiang#, Bin Chen#, Junhao Jiang, Yun Shi, Tao Ma, Weiguo Fu*,Zhihui Dong*. Outcomes of endovascular therapy for Stanford type Baortic dissection in patients with Marfan syndrome. J ThoracCardiovasc Surg. 2021 Jun 9:S0022-5223(21)00899-0.

13.JiangX#, Liu H#, Pan T#, Gu S, Fang Y, Wei Z, Fang G, Chen B, Jiang J,Shi Y, Liu P, Fu W*, Dong Z*. Long-Term Outcomes of PeripheralBlood Mononuclear Cells in the Treatment of Angiitis-InducedNo-Option Critical Limb-Threatening Ischemia. Front CardiovascMed. 2021 Dec 6;8:769472.

14.LingweiZou#; Hao Liu#; Xiaolang Jiang; Bin Chen; Junhao Jiang; Yun Shi;Tao Ma; Changpo Lin; Weiguo Fu*; Zhihui Dong*. Long-term outcomesof endovascular treatment for aortic pseudoaneurysm in patientswith Behçet's disease, Vascular, 2021:17085381211063038. doi:10.1177/17085381211063038.

15.JiangX#, Fang G#, Guo D, Xu X, Chen B, Jiang J, Dong Z*, Fu W*.Surgical Management of Carotid Body Tumor and Risk Factors ofPostoperative Cranial Nerve Injury. World J Surg.2020;44(12):4254-4260.

16.FangG#, Jiang X#, Fang Y, Pan T, Liu H, Ren B, Wei Z, Gu S, Chen B,Jiang J, Shi Y, Guo D, Liu P, Fu W*, Dong Z*. Autologousperipheral blood-derived stem cells transplantation for treatmentof no-option angiitis-induced critical limb ischemia: 10-yearmanagement experience. Stem Cell Res Ther. 2020;11(1):458.

17.JiangX, Shi Y, Chen B, Jiang J, Ma T, Lin C, Guo D, Xu X, Dong Z*, FuW. Long-term results of extensive aortoiliac occlusive disease(EAIOD) treated by endovascular therapy and risk factors for lossof primary patency. Chin Med J (Engl). 2021134(8)913-919.

18.XiaolangJiang#, Tianyue Pan#, Lingwei Zou, Bin Chen, Junhao Jiang, YunShi, Tao Ma, Changpo Lin, Daqiao Guo, Xin Xu, Jue Yang, ZhenyuShi, Ting Zhu, Zhihui Dong*, Weiguo Fu. Outcomes of endovascularstent graft repair for penetrating aortic ulcers with or withoutintramural hematoma. J Vasc Surg. 2021 May;73(5):1541-1548.

19.XiaoxinKan#, Tao Ma#, Zhihui Dong*, Xiao Yun Xu*. Patient-SpecificVirtual Stent-Graft Deployment for Type B Aortic Dissection: APilot Study of the Impact of Stent-Graft Length. Frontiers inPhysiology. 2021;12:718140.

20.ChlöeH Armour, Baolei Guo, Simone Saitta, Selene Pirola, Yifan Liu,Zhihui Dong*, Xiao Yun Xu*. Evaluation and verification ofpatient-specific modelling of type B aortic dissection. Computersin Biology and Medicine. 2021;140:105053.

21.ZhuangyuanMeng#, Tao Ma#, Yunhan Cai, Xudong Liu, Shengzhang Wang*, ZhihuiDong*, Weiguo Fu. Numerical modeling and simulations of type Baortic dissection treated by stent-grafts with differentoversizing ratios. Artificial Organs. 2020;44(11):1202-1210.

22.HaoLiu#, Tianyue Pan#, Yuan Fang, Gang Fang, Yifan Liu, XiaolangJiang, Bin Chen, Zheng Wei, Shiyang Gu, Peng Liu, Weiguo Fu*,Zhihui Dong*. Three-year outcomes of PBMNCs versus PCCs in thetreatment of Angiitis-induced no-option critical limb ischemia anda cost-effectiveness assessment. Stem Cell Tran Med, 2020.

23.ChlöeHarrietArmour#; Baolei Guo#;Selene Pirola; Simone Saitta; Yifan Liu;Zhihui Dong*; Xiaoyun Xu*; The influence of inlet velocity profileon predicted flow in type B aortic dissection, Biomech ModelMechanobiol, 2021;20(2):481-490  

24.FangG#, Fang Y#, Xu X, Yang J, Zhu T, Yue J, Fu W*, Dong Z*. Long-termoutcomes of endovascular treatment of isolated subclavian arteryaneurysms. Vascular. 2020:1708538120975242.

25.FangG#, Xu GY#, Fang Y, Yang J, Pan T, Jiang X, Luo J, Dong Z,Fu W.Primary conservative treatment for peritonitis-absent symptomaticisolated dissection of the superior mesenteric artery withseverely compressed true lumen. Vascular, 2020, 28(2):132-141.

26.FangG#, Chen B, Guo DQ, Xu X, Jiang JH, Shi ZY, Dong ZH*, Fu WG.Treatment of popliteal artery aneurysm-induced emergencies. ChinMed J, 2020,133(01) : 94-96.

27.FangG#, Xu GY#, Fang Y, Yang J, Pan T, Jiang X, Luo J, Dong Z,Fu W.Primary conservative treatment for peritonitis-absent symptomaticisolated dissection of the superior mesenteric artery withseverely compressed true lumen. Vascular, 2020, 28(2):132-141.

28.ZhuangyuanMeng, Tao Ma, Shengzhang Wang*, Zhihui Dong* and Weiguo Fu. FiniteElement Analysis for Type B Aortic Dissection Treated with TwoTypes of Stent Grafts. Molecular and Cellular Biomechanics, 2019,16(s1):19-21.

29.GuoB#, Dong Z#, Pirola S#, Liu Y, Menichini C, Xu XY, Guo D, Fu W.Dissection Level Within Aortic Wall Layers is Associated withPropagation of Type B Aortic Dissection: A Swine Model Study. EurJ Vasc Endovasc Surg. 2019; 58:415-425.

30.LiuY#, Pan T#, Hou K, Dong Z,Fu W.Multiple Overlapping Stent Implantation Combined with CoilEmbolization for a Suprarenal Aortic Pseudoaneurysm with ImpendingRupture in a Patient with Behçet's Disease. Ann Vasc Surg. 2019May 7. pii: S0890-5096(19)30304-8.

31.SelenePirola#; Baolei Guo#; Claudia Menichini; Simone Saitta; Weiguo Fu;Zhihui Dong*; Xiaoyun Xu*; 4D Flow MRI-Based ComputationalAnalysis of Blood Flow in Patient-Specific Aortic Dissection, IEEETransactions on Biomedical Engineering, 2019, 66(12):3411-3419.

32.PanT#, Liu H#, Fang Y, Wei Z, Gu S, Fang G, Liu Y, Luo Y, Guo D, XuX, Chen B, Jiang J, Yang J, Shi Z, Zhu T, Shi Y, Liu P, Dong Z,Fu W.Predictors of responders to mononuclear stem cell-basedtherapeutic angiogenesis for no-option critical limb ischemia.Stem Cell Res Ther. 2019 Jan 11;10(1):15. doi:10.1186/s13287-018-1117-5.

33.MaT#, Dong ZH#, Wang S, Meng ZY, Chen YY, Fu WG.Computational investigation of interaction between stent graft andaorta in retrograde type A dissection after thoracic endovascularaortic repair for type B aortic dissection. J Vasc Surg. 2018;68:14S-21S.

34.DongZ#,Pan T#, Fang Y, Wei Z, Gu S, Fang G, Liu Y, Luo Y, Liu H, Zhang T,Hu M, Guo D, Xu X, Chen B, Jiang J, Yang J, Shi Z, Zhu T, Shi Y,Liu P, Fu W.Purified CD34(+) cells versus peripheral blood mononuclear cellsin the treatment of angiitis-induced no-option critical limbischaemia: 12-Month results of a prospective randomisedsingle-blinded non-inferiority trial. EBioMedicine. 2018; 35:46-57.

35.MenichiniC, Pirola S, Guo B, Fu W, Dong Z,Xu XY. High Wall Stress May Predict the Formation of Stent-Graft-InducedNew Entries After Thoracic Endovascular Aortic Repair. J EndovascTher. 2018, 25(5) : 571–577.

36.FangY#, Wei Z#, Chen B, Pan T, Gu S, Liu P, Guo D, Xu X, Jiang J, YangJ, Shi Z, Zhu T, Shi Y, Liu Y, Dong Z,Fu W.A Five-Year Study of the Efficacy of Purified CD34+ Cell Therapyfor Angiitis-Induced No-Option Critical Limb Ischemia. Stem CellsTransl Med. 2018; 7: 583-590.

37.FangG#, Chen B#, Fu W, Guo D, Xu X, Jiang J, Luo J, Dong Z.Strategies for endovascular treatment of complicated splenicartery aneurysms. J Vasc Surg. 2018; 68: 787-94.  

38.PanTY#, Wei Z#, Fang Y, Dong ZH,Fu WG.Therapeutic Efficacy of CD34+ Mononuclear Cell Therapy forNo-option Critical Limb Ischemia: A Meta-analysis of RandomizedControlled Clinical Trials. Vasc Med.  2018 Jun;23(3):219-231.  

39.WangD#, Ma T#, Guo D, Xu X, Chen B, Jiang J, Yang J, Shi Z, Zhu T, ShiY, Dong Z,Fu W.Endovascular treatment of acute and chronic isolated abdominalaortic dissection. Vascular. 2018, 26(4): 418-24.

40.MaT#, Dong ZH#, Fu WG,Guo DQ, Xu X, Chen B, Jiang JH, Yang J, Shi ZY, Zhu T, Shi Y,Jiang BH, Xu XY. Incidence and risk factors for retrograde type Adissection and stent graft-induced new entry after thoracicendovascular aortic repair. J Vasc Surg. 2018;67(4):1026-1033.e2.

41.DongZH, Fu WG,Wang YQ, Guo DQ, Xu X, Ji Y, Chen B, Jiang JH, Yang J, Shi ZY, ZhuT, Shi Y. Retrograde Type A Aortic Dissection After EndovascularStent Graft Placement for Treatment of Type B Dissection.Circulation, 2009, 119(5):735-741.



主要著作

1.《系统性血管炎》第二版,人民卫生出版社。主编:姜林娣。副主编:田新平,郑毅,董智慧。主审:曾小峰,赵岩,顾越英。

2.《血管和血管腔内手术要领与图解》,中南大学出版社,20217月。主译:符伟国,陈兵。副主译:董智慧,刘震杰。书号:ISBN978-7-5478-4391-0764千字。

3.《血管和腔内血管外科学精要》(Masteryof Vascular and Endovascular Surgery ),天津科技翻译出版公司,20101月。主译:郭伟  符伟国。 副主译:熊江  董智慧。主审:王玉琦。书号:ISBN978-7-5433-2543-2800千字。

4.“十二五”国家重点图书《卢瑟福血管外科学》第7版,(RutherfordVascular Surgery),北京大学医学出版社,201210月。主译:郭伟 符伟国,陈忠。 副主译:熊江  董智慧,王盛。书号:ISBN978-7-5659-0410-32622千字。

5.《血管手术疑难病例解析》,人民军医出版社,201512月。主审:张小明,符伟国,陈学明,庄百溪。主编:郑月宏,张望德,李春民。副主编:冯海,董智慧,马鲁波,樊雪强。书号:ISBN978-7-5091-8867-5400千字。

6.《泛血管医学——概念及常见疾病诊治》,人民卫生出版社,20188月。主编:葛均波,王拥军。书号:ISBN978-7-117-27107-3438千字。参编。

7.《实用外科学》,人民卫生出版社,20178月。主编:吴肇汗,秦新裕,丁强。书号:ISBN978-7-117-23988-25688千字。参编。

8.《主髂动脉外科学》,人民军医出版社,201611月。主编:郑月红,李春民,符伟国,王豪夫。书号:ISBN978-7-5091-9229-0583千字。参编



专利

1邹凌威;董智慧;刘浩;符伟国;陈斌;蒋俊豪;石赟;马韬;一种改良式股动脉压迫止血器,2022-2-25,中国(实用新型)ZL202121477934.6

2郭宝磊;符伟国;郭大乔;董智慧;一种主动脉夹层腔内修复术后假腔血流状态评价方法,2021-9-6 , 中国,202111037207.2

3潘天岳;董智慧;符伟国;郭大乔;陈斌;蒋俊豪;方圆;魏征;顾史洋;一种兼顾输入和多路输出的封闭式移植物回输装置,2019-06-04,中国,201720899941.2.(发明专利)

4郭宝磊;董智慧;符伟国;郭大乔;陈斌;史振宇;一种可控性多发破口主动脉夹层模型的建立方法,2018-4-28, 中国,201810399989.6

5非对称型人工血管内支架及其制备方法(ZL200420082003.6),符伟国,董智慧,王玉琦,郭大乔,徐欣,陈斌,蒋俊豪,杨珏,史振宇。(实用新型,已授权)

6新型颈动脉支架脑保护装置回收器材(ZL201420440244.7),蒋俊豪,杨珏,董智慧,石赟,马韬。授权公告日:2014-12-10。(实用新型,已授权)

7以纤维蛋白原为基础的三维多孔纳米支架及其制备方法,发明人,符伟国、方征东、董智慧、张祥满、郭大乔、何红兵、王玉琦。专利号ZL2010 1 0107257. 9 。授权公告日:2014-01-22。(发明专利,已授权并转让)

8卢伟锋、蔡秋妮、熊宇、张祥满、董智慧、陈小丽,一种微血管灌注实验设备 , 申请号CN201420261099.6,专利号ZL2014 2 0261099.6。申请日期2014-05-21,授权公告日2014-10-29。实用新型。

9卢伟锋、蔡秋妮、熊宇、张祥满、董智慧、陈小丽,一种基于同步辐射技术下微血管成像实验设备,申请号CN201420261125.5.。专利号ZL2014 2 0261125.5。申请日期2014-05-21,授权公告日2014-10-29。实用新型。

10中国专利,郭宝磊;董智慧;符伟国;郭大乔;陈斌;史振宇,一种可控性多发破口主动脉夹层模型的建立方法,申请,2018.8.24, 201810399989.6

11中国专利,郭宝磊;符伟国;郭大乔;董智慧;张超,一种猪胸主动脉夹层模型的构建方法,申请,2016.4.1, 201610420844.0

12中国实用新型专利:潘天岳,董智慧,符伟国,郭大乔,陈斌,蒋俊豪,方圆,魏征,顾史洋。一种兼顾输入和多路输出的封闭式移植物回输装置。申请日2017-07-24,授权日2019-06-04201720899941.2

四、主要社会学术团体兼职

1.2019-11至今,中国医师协会血管外科医师分会胸主动脉学组,委员兼秘书

2.2017-08至今,上海市医学会血管外科分会,委员兼秘书

3.2019-12至今,上海市医师协会血管外科医师分会,委员兼秘书

4.2021-11至今,国际血管联盟(IUA)中国分部,副秘书长

5.2021-11至今,国际血管联盟(IUA)中国分部胸主动脉学组,副主任委员

6.2015-12-07,上海普外临床质控中心血管外科专家组 委员兼秘书

7.上海市医学会风湿病学分会血管炎学组副组长

8.2016-至今:中华细胞与干细胞杂志(电子版),编委

9.2013-11至今,“中华医学会医学工程分会干细胞工程专业委员会”委员

10.2015-09至今,“中国心血管医生创新俱乐部”(Centerfor Cardiovascular Innovations, CCI)核心会员

11.2009-06至今,“美国血管外科学会”会员 (Societyfor Vascular Surgery

12.“国际血管腔内专家学会”会员(InternationalSociety of Endovascular Specialist

13.2020-01至今,Journalof Endovascular Therapy, 编委

14.中华细胞与干细胞杂志,编委

15.《中华实验外科杂志》通讯编委

16.《中国临床医学》审稿专家

17.《临床误诊误治杂志》编委

五、主要研究方向

  1. 主动脉夹层生物力学


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