三、主要科研工作与成绩 科研项目 1国家自然基金(面上)编号:81772591题目:胰腺癌细胞通过Hedgehog-外泌体MALAT-1途径促进周围神经侵犯的机制研究 经费:50万元时间:2018.1.1-2021.12.31第一承担人 2国家自然基金(面上)编号:81172312题目:Hh信号通路通过两阶段模式促进胰腺癌新生血管生成的机制研究经费:55万元,时间:2011.1-2015.12第一承担人 3上海市自然基金编号:17ZR1427000题目:胰腺癌变分子网络中的新通路“SHh-Gli1-APOBEC3B轴”的作用机制研究经费:20万元时间:2017.1-2020.12第一承担人 4上海市科委自然基金编号:10ZR1423300题目:Gli1调控PDGF-B基因促进胰腺癌新生血管生成的机制经费: 10万元,时间:2010.1-2013.12第一承担人 5上海市卫生和计划生育委员会(面上)编号:201740156题目:胰腺癌细胞通过Hedgehog-外泌体MALAT-1途径促进周围神经侵犯的机制研究经费:102018.1.1-2020.12.31第一承担人 6上海市卫生和计划生育委员会(面上)编号:2009142题目:Hh信号通路在胰腺癌靶向治疗中的价值研究经费:4万元时间:2010.1-2013.12第一承担人 论文 Mo,W ; Dai, Y ; Chen, J ; Xu, X ;Long Noncoding RNA (lncRNA)MT1JP Suppresses Hepatocellular Carcinoma (HCC) in vitro. CancerManag Res. 2020; 12: 7949-7960 XuS, Xu X. Research Advances in the Correlation between PeroxisomeProliferator-Activated Receptor-γ and Digestive Cancers. PPARRes. 2018; 2018: 5289859. ZhangH, Yang W, Li Y, Hu L, Dai Y, Chen J, Xu S, Xu X, Jiang H.Astaxanthin ameliorates cerulein-induced acute pancreatitis inmice. Int Immunopharmacol. 2018; 56: 18-28. ZhangH, Xu X. Mutation-promoting molecular networks of uncontrolledinflammation. Tumour Biol. 2017; 39(6): 1010428317701310. ZhangH, Li Y, Li L, Liu H, Hu L, Dai Y, Chen J, Xu S, Chen W, Xu X, XuX. Propylene Glycol Alginate Sodium Sulfate Alleviates Cerulein-Induced Acute Pancreatitis by Modulating the MEK/ERKPathway in Mice.Mar Drugs. 2017; 15(2). pii: E45. GanH, Liu H, Zhang H, Li Y, Xu X, Xu X, Xu J. SHh-Gli1 signalingpathway promotes cell survival by mediating baculoviral IAPrepeat-containing 3 (BIRC3) gene in pancreatic cancer cells.Tumour Biol. 2016; 37(7): 9943-50. ZhouYQ, Xu L, Wang BF, Fan XM, Wu JY, Wang CY, Guo CY, Xu XF.Modified Sequential Therapy Regimen versus Conventional TripleTherapy for Helicobacter Pylori Eradication in Duodenal UlcerPatients in China: A Multicenter Clinical Comparative Study.Gastroenterol Res Pract. 2012; 2012: 405425. XuX, Liu H, Zhang H, Dai W, Guo C, Xie C, Wei S, He S, Xu X. SonicHedgehog-GLI Family Zinc Finger 1 Signaling Pathway Promotes theGrowth and Migration of Pancreatic Cancer Cells by Regulating theTranscription of Eukaryotic Translation Initiation Factor 5A2.Pancreas. 2015; 44(8): 1252-8. LiuH, Xu XF, Zhao Y, Tang MC, Zhou YQ, Gao FH. NS-398 promotespancreatic cancer cell invasion by CD147 and MMP-2 via theactivation of P38. Mol Med Rep. 2016; 13(3): 2208-14. LiuH, Xu XF, Zhao Y, Tang MC, Zhou YQ, Lu J, Gao FH. MicroRNA-191promotes pancreatic cancer progression by targeting USP10. TumourBiol. 2014; 35(12): 12157-63. XuX, Xu X, Ciren Y, Feng B, Tao C, Xia Y, Liu Z. Chemopreventiveeffects of 5-amino salicylic acids on inflammatory boweldisease-associated colonic cancer and colonic dysplasia: ameta-analysis. Int J Clin Exp Med. 2015; 8(2): 2212-2218. XuX, Su B, Xie C, Wei S, Zhou Y, Liu H, Dai W, Cheng P, Wang F, XuX, Guo C. Sonic hedgehog-Gli1 signaling pathway regulates theepithelial mesenchymal transition (EMT) by mediating a new targetgene, S100A4, in pancreatic cancer cells. PLoS One. 2014; 9(7):e96441. XuX, Zhou Y, Xie C, Wei SM, Gan H, He S, Wang F, Xu L, Lu J, Dai W,He L, Chen P, Wang X, Guo C. Genome-wide screening reveals an EMTmolecular network mediated by Sonic hedgehog-Gli1 signaling inpancreatic cancer cells. PLoS One. 2012;7(8):e43119. MoW, Xu X, Xu L, Wang F, Ke A, Wang X, Guo C. Resveratrol inhibitsproliferation and induces apoptosis through the hedgehogsignaling pathway in pancreatic cancer cell. Pancreatology.2011;11(6):601-9. ZhouY, Xu X, Xu L, Xu Y, Lu J, Wu D, Wang X, Guo C. Treatment ofprimary isolated extramedullary plasmacytoma of esophagus withendoscopic submucosal dissection. Clin Gastroenterol Hepatol.2012; 10(3): e21-2. XuXF, Guo CY, Liu J, Yang WJ, Xia YJ, Xu L, Yu YC, Wang XP. Gli1maintains cell survival by up-regulating IGFBP6 and Bcl-2 throughpromoter regions in parallel manner in pancreatic cancer cells. JCarcinog. 2009; 8:13. XuXF, Xie CG, Wang XP, Liu J, Yu YC, Hu HL, Guo CY. Selectiveinhibition of cyclooxygenase-2 suppresses the growth ofpancreatic cancer cells in vitro and in vivo. Tohoku J Exp Med.2008; 215(2): 149-57.
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