三、主要科研工作与成绩 主持和参与的项目： UHRF2 介导DNA-5’羟甲基化调控卵巢功能的研究, 22ZR1456400，上海市自然科学基金面上项目 , 2022-04 至 2025-04, 20万, 在研, 主持。 通过碱基编辑工具筛选调节脂代谢相关的点突变, 21JC1402204, 上海市基础研究领域项目/生物前沿基础与技术支撑, 2021-10 至 2024-09, 40万元, 在研, 主持。 基于新型碱基编辑技术的细胞突变株构建及其工艺优化，合同号022310035001280，横向开发，2022-10至2025-10，9万，在研，主持。 Uhrf2基因缺失致卵泡发育异常的分子基础及机制研究, 31701303，国家自然科学基金青年项目, 2018-01-01 至 2020-12-31, 20万元, 结题, 主持 Ndrg3基因在精子发生中的功能及其与少、弱精症的关系研究, 20144Y0211, 上海市卫生和计划生育委员会, 青年类项目, 2015-01 至 2017-12, 2万元, 结题, 主持 Ndrg3基因在精子发生中的功能与机制研究, 14ZR1435400, 上海市自然科学基金青年类, 2014-07 至 2017-06, 10万元, 结题, 主持。 Znhit1基因通过H2A.Z基因参与精子发生过程中减数分裂的研究, 81971443, 国家自然科学基金面上项目, 2020-01-01 至 2023-12-31, 55万元, 在研, 参与。
代表论文： Hongjie Pan; NingJiang; Shenfei Sun; Hanwei Jiang; Jianze Xu; Xiaohua Jiang; Qian Gao; Liang Li; Haili Wu; Huajun Zheng; Qi Qi; Tianqi Li; Meixing Zhang; Lingling Zhang; Xiaofeng Wan; Xinhua Lin; Jiemin Wong; Qinghua Shi; Runsheng Li ; UHRF1-repressed 5'-hydroxymethylcytosine is essential for the male meiotic prophase I., Cell Death & Disease, 2020, 11(2): 0-142 Shenfei Sun, Yamei Jiang, Qiaoli Zhang, Hongjie Pan, Xinyang Li, Li Yang, Meina Huang, Wei Wei, Xiaoye Wang, Mengdi Qiu, Lihuan Cao, Hua He, Miao Yu, Hanmin Liu, Bing Zhao, Ning Jiang, Runsheng Li, Xinhua Lin Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression. Dev Cell. 2022 Apr 11; 57(7):901-913.e4. doi: 10.1016/j.devcel.2022.03.006. Yaohua Yuan, Haili Wu, Hongjie Pan. Comparative analysis of the fecal microbiome and metabolomics of healthy versus captive South China tigers with mild diarrhea. Can J Microbiol. 2022 Dec 1;68(12):758-768.doi: 10.1139/cjm-2022-0115. Epub 2022 Oct 4. Weiqi Sun, Fang Tian, Hongjie Pan , Xiuli Chang, Minjie Xia, Jingying Hu , Yuzhu Wang , Runsheng Li, Weihua Li, Mingjun Yang, Zhijun Zhou. Flurochloridone induced abnormal spermatogenesis by damaging testicular Sertoli cells in mice. Ecotoxicol Environ Saf. 2022 Nov;246:114163.doi: 10.1016/j.ecoenv.2022.114163. Epub 2022 Oct 11. (共第一) Haili Wu, Yaohua Yuan, Hongjie Pan Comparison of fecal microbiota composition of blue sheep fed Lolium perenne versus Sorghum sudanense. Can J Microbiol. 2021 May;67(5):372-380. doi: 10.1139/cjm-2020-0333. Wei Yang, Yanyi Xu, Hongjie Pan, Fang Tian, Yuzhu Wang, Minjie Xia, Jingying Hu, Mingjun Yang, Shimin Tao, Shenfei Sun, Haidong Kan, Runsheng Li, Zhekang Ying, Weihua Li Chronic exposure to diesel exhaust particulate matter impairs meiotic progression during spermatogenesis in a mouse model. Ecotoxico Environ Saf.2020 Oct 1;202:110881. doi: 10.1016/j.ecoenv.2020.110881. Epub 2020 Jun 20. (共第一) Xue Tan; Lingling Zhang; Tianqi Li; Jianmin Zhan; Kun Qiao; Haili Wu; Shenfei Sun; Meina Huang; Fangxi Zhang; Meixing Zhang; Changwei Li; Runsheng Li; Hongjie Pan ; Lgr4 Regulates Oviductal Epithelial Secretion Through the WNT Signaling Pathway, Frontiers in Cell and Developmental Biology, 2021, 9 Hongjie Pan, Xuan Zhang, Hanwei Jiang, Xiaohua Jiang, Liu Wang, Qi Qi, Yuan Bi, Jian Wang, Qinghua Shi, Runsheng Li Ndrg3 gene regulates DSB repair during meiosis through modulation the ERK signal pathway in the male germ cells. Sci Rep. 2017 Mar 14;7:44440. doi: 10.1038/srep44440. Hongjie Pan; Hengxiang Cui; Shijie Liu; Yu Qian; Haili Wu; Liang Li; Yuting Guan; Xin Guan; Long Zhang; Heng-Yu Fan; Yanlin Ma; Runsheng Li; Mingyao Liu; Dali Li ; Lgr4 gene regulates corpus luteum maturation through modulation of the WNT-mediated EGFR-ERK signaling pathway., Endocrinology., 2014, 155(9): 2013-2183
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