三、主要科研工作与成绩 1.科研项目 1)国家自然科学基金优秀青年基金,2022.1-2024.12 2)国家自然科学基金面上项目,2023.1-2026.12 3)国家自然科学基金面上项目,2019.1-2022.12 4)国家自然科学基金面上项目,2015.1-2018.12 2.代表性论著 1)CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety. Cell Discovery, 2023,9(1):94 2)Aberrant TGF-beta1 signaling activation by MAF underlies pathological lens growth in high myopia. Nat Commun2021;12:2102. 3)DNA hypermethylation-mediated downregulation of antioxidantgenescontributestotheearlyonsetofcataractsinhighlymyopiceyes,RedoxBiol, 2018.8.23,19:179-189 4)Single-cell RNA sequencing of retina revealed novel transcriptional landscape in high myopia and underlying cell-type-specific mechanisms. MedComm. 2023,4(5):e372 5)Single-cellRNAsequencing: Inhibited Notch2 signalling underlying the increased lens fibre cells differentiation in high myopia. Cell Prolif2023;56:e13412. 3.主编/参编教材 1)儿童眼科临诊治学习精要,2022.5,副主编 2)眼科临床指南解读:白内障,2018.8,编写秘书 4.发明专利 1)一种高度近视白内障人工晶状体精准选择系统,专利号:ZL 2019 1 0502354.9 2)一种高度近视白内障手术预后智能预判系统,专利号:ZL 201910294447.7 3)一种适用于高度近视并发开角型青光眼的智能筛查系统及其建立方法,专利号ZL 201811373868.0 |