三、主要科研工作与成绩 主持科研项目： 项目名称: GraRS信号转导阻断对金黄色葡萄球菌在慢性鼻窦炎中致病作用的调控机制研究;项目编号：20ZR1410000 上海市“科技创新行动计划”自然科学基金项目 项目名称: Reboot手术及翼管神经切断术治疗难治性嗜酸型慢性鼻窦炎的多中心随机对照单盲研究;设项单位：复旦大学附属眼耳鼻喉科医院“双优”临床实验资助计划 项目名称：上海市青年医师培养计划 项目名称：吸烟诱导金黄色葡萄球菌生物膜形成机制及相关治疗的研究;设项单位：国家自然科学基金委员会
第一作者或通讯作者论著： Chen L, Wang Z, Xu T, Ge H, Zhou F, Zhu X, Li X, Qu D, Zheng C, Wu Y, Zhao K.The Role of graRS in Regulating Virulence and Antimicrobial Resistance in Methicillin-Resistant Staphylococcus aureus. Front Microbiol. 2021 Aug 16;12:727104. （IF:5.640）共同通讯作者 Lun Xu,Ke-Qing Zhao,Hong-Meng Yu. Combined Endoscopic and Transoral Approach for Total Maxillectomy. JoVE.2021 Feb 26;(136). 共同通讯作者 Min Li, Yadong Xie, Keqing Zhao, Kun Chen, Yujie Cao, Jia Zhang, Miaomiao Han, Li Hu, Rui He, Dehui Wang and Huabin Li Endoplasmic reticulum stress exacerbates inflammation in chronic rhinosinusitis with nasal polyps via the transcription factor XBP1. Clinical immunology. 2020.12.25 （IF:3.368）共同第一作者 Le Shi, Yang Wu, Chen Yang, Yue Ma, Qing-zhao Zhang, Wei Huang, Xiao-yi Zhu, Ying-jie Yan, Jia-xue Wang, Tao Zhu, Di Qu, Chun-quan Zheng, Ke-Qing Zhao. Effect of nicotine on Staphylococcus aureus biofilm formation and virulence factors. Scientific Report. 2019 Dec 27；9（1）20243. (IF: 4.011) 通讯作者 Jinna Bai, Xiaoyi Zhu, Keqing Zhao, Yingjie Yan, Tao Xu, Jiaxue Wang, Jinxing Zheng, Wei Huang, Le Shi, Yongpeng Shang, Zhihui Lv, Xiaofei Wang, Yang Wu, Di Qu. The role of ArlRS in regulating oxacillin susceptibility and biofilm formation in methicillin-resistant Staphylococcus aureus indicates it is a potential target for antimicrobial resistance breakers. Emerging Microbes & Infections. 2019.8 (IF:6.032) 共同第一作者 Yang Wu, Yue Ma, Tao Xu, Qing-zhao Zhang, Jinna Bai, Jiaxue Wang, Tao Zhu, Qiang Lou, Friedrich Götz, Di Qu, Chun-quan Zheng, Ke-qing Zhao. Nicotine enhances Staphylococcus epidermidis biofilm formation by altering the bacterial autolysis, extracellular DNA releasing, and polysaccharide intercellular adhesin production. Frontiers in Microbiology. 2018 Oct 29;9:2575 doi: 10.3389/fmicb.2018.02575 (IF:4.019) 通讯作者 Zhao KQ, Yu YQ, Yu HM. Effects of mometasone furoate-impregnated biodegradable nasal dressing on endoscopic appearance in healing process following endoscopic sinus surgery: a randomized, double-blind, placebo-controlled study. Int Forum Allergy Rhinol. 2018 Oct 3. doi: 10.1002/alr.22213. 8卷11期：1233-1241. (IF: 2.454) 第一作者 Zhao KQ, Pu SL, Yu HM. Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation. JoVE. 2018 Jun 20;(136). doi: 10.3791/57678. (IF: 1.232) 第一作者 Yue Ma, Shuai Wu, Shan Zhu, Chunquan Zheng, Keqing Zhao. Prognosis and linicopathology of long non-coding RNA HOTTIP in tumors. Int J Clin Exp Med 2018;11(6):5820-5828. (IF: 1.069) 通讯作者 Ke-Qing Zhao, Yang Wu, Yu-Xi Yi, Si-Jia Feng, Ruo-yan Wei, Ying Ma, Chun-Quan Zheng1, Di Qu. An In Vitro Model to Study the Effect of 5-Aminolevulinic Acid-mediated Photodynamic Therapy on Staphylococcus Aureus Biofilm. JoVE. 2018. Apr 16；（134）doi: 10.3791/57604. (IF: 1.232) 第一作者，通讯作者 Zhang QZ, Zhao KQ, Wu Y, Li XH, Yang C, Guo LM, Liu CH, Qu D, Zheng CQ. 5-aminolevulinic acid-mediated photodynamic therapy and its strain-dependent combined effect with antibiotics on Staphylococcus aureus biofilm. PLoS One. 2017 Mar 30;12(3):e0174627. doi: 10.1371/journal.pone.0174627. eCollection 2017. （IF:2.806）共同第一作者 赵可庆，杨晨，吴旸，郭丽敏，刘华勇，吉建，陈小英，郑春泉。5-氨基酮戊酸光动力疗法对不同疾病来源的耐甲氧西林金黄色葡萄球菌的体外杀伤作用。微生物与感染（中国科技核心期刊），2016第4期：228-233第一作者，通讯作者。 赵可庆，杨晨，丁国强，刘春红，马苏，陈小英，吴旸，郑春泉。光敏疗法对慢性鼻-鼻窦炎患者耐药葡萄球菌体外杀伤效果的研究。中华耳鼻咽喉头颈外科杂志（A类），2016第03期：167-171。第一作者 赵可庆，郑春泉。慢性鼻-鼻窦炎相关因素与继发性纤毛功能失调的研究进展。中国眼耳鼻喉科杂志，2015,15（5）:362-365.中国科技核心期刊，第一作者 Zhao KQ, Cowan AT, Lee RJ, Goldstein N, Droguett K, Chen B, Zheng C, Villalon M, Palmer JN, Kreindler JL, Cohen NA. Molecular modulation of airway epithelial ciliary response to sneezing. FASEB J. 2012 Aug;26(8):3178-87. 影响因子：6.515 被引用1次 Zhao KQ, Xiong G, Wilber M, Cohen NA, Kreindler JL. A role for two-pore K⁺channels in modulating Na⁺ absorption and Cl⁻secretion in normal human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2012 Jan;302(1): L4-L12. Epub 2011 Sep 30. PubMed PMID: 21964404. 影响因子：4.137 被引用6次 Zhao KQ, Goldstein N, Yang H, Cowan AT, Chen B, Zheng C, Palmer JN, Kreindler JL, Cohen NA. Inherent differences in nasal and tracheal ciliary function in response to Pseudomonas aeruginosa challenge. Am J Rhinol Allergy. 2011 Jul-Aug;25(4):209-13. PubMed PMID: 21819755. 影响因子：2.252 被引用6次 赵可庆,翟立杰,王志强,冯亚,高明珠。基因芯片筛选骨髓间充质干细胞与透明软骨细胞的差异表达基因.《大连医科大学学报》:2008年05期.
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