三、主要科研工作与成绩 主持科研项目: 嗜热链球菌碳代谢调控高密度培养的机制研究,国家自然科学基金青年项目 基于基因组大数据和基因编辑乳酸菌益生机制的解析,国家自然科学基金联合项目 嗜热链球菌基因组规模代谢网络调控高密度培养策略研究,中国食品科学技术学会青年基金
代表性论文: 1. Song, X.; Li, Y. L.; Xia, Y. J.; Wang, G. Q.; Xiong, Z. Q.; Yang, Y.; Ai, L. Z*. Phage Tyrosine Integrase-Mediated Multi-Sites Genome Engineering in Lacticaseibacillus Casei. Food Biosci 2024, 58, 103694. 2. Song, X.; Liu, L.; Liu, X. X.; Xiong, Z. Q.; Xie, C. L.; Wang, S. J.; Ai, L. Z*. Single-Plasmid Systems Based on CRISPR-Cas9 for Gene Editing in Lactococcus Lactis. J. Dairy Sci 2021, 104 (10), 10576–10585. 3. Song, X.#; Huang, H.#; Xiong, Z. Q.; Ai, L. Z.; Yang, S*. CRISPR-Cas9D10A Nickase-Assisted Genome Editing in Lactobacillus Casei. Appl Environ Microbiol 2017, 83 (22), e01259-17. 4. Wang, H.; Ai, L. Z.; Xia, Y. J.; Wang, G. Q.; Xiong, Z. Q.; Song, X*. Software-Based Screening for Efficient sgRNAs in Lactococcus Lactis. J Sci Food Agric 2024, 104 (2), 1200–1206. 5. Song, X.#; Zhang, X. Y.#; Xiong, Z. Q.; Xia, Y. J.; Wu, Y.; Ai, L. Z.; Xu, H.; Tian, Y. J.; Yang, Y. J.; Wang, G. Q*. Characterization of Endogenous Constitutive Promoters from Lactobacillus Salivarius for Finely-Tuning Gene Expression. Food Biosci 2022, 50, 101980. 6. Song, X.; Huang, H.; Xiong, Z. Q.; Xia, Y. J.; Wang, G. Q.; Yin, B. X; Ai, L. Z*. Characterization of a Cryptic Plasmid Isolated from Lactobacillus Casei CP002616 and Construction of Shuttle Vectors Based on Its Replicon. J. Dairy Sci 2018, 101 (4), 2875–2886. 7. Song, X.; Xiong, Z. Q.; Kong, L. H.; Wang, G. Q.; Ai, L. Z*. Relationship Between Putative Eps Genes and Production of Exopolysaccharide in Lactobacillus Casei LC2W. Front Microbiol 2018, 9, 1882. 8. Song, X.; Hou, C. J.; Yang, Y.; Ai, L. Z.; Xia, Y. J.; Wang, G. Q.; Yi, H. X.; Xiong, Z. Q*. Effects of Different Carbon Sources on Metabolic Profiles of Carbohydrates in Streptococcus Thermophilus During Fermentation. J Sci Food Agric 2022, 102 (11), 4820–4829. 9. Song, X.; Li, F. J.; Zhang, M. S.; Xia, Y. J.; Ai, L. Z.; Wang, G. Q*. Effect of D-Ala-Ended Peptidoglycan Precursors on the Immune Regulation of Lactobacillus Plantarum Strains. Front Immunol 2022, 12, 825825. 10. Wang, G. Q. #; Yu, H. N. #; Feng, X.; Tang, H. Y.; Xiong, Z. Q.; Xia, Y. J.; Ai, L. Z.; Song, X*. Specific Bile Salt Hydrolase Genes in Lactobacillus Plantarum AR113 and Relationship with Bile Salt Resistance. LWT 2021, 145, 111208. |