舒易来-硕博士研究生指导教师

发布者：董尹发布时间：2024-02-05浏览次数：30

姓名

舒易来

职称

教授、主任医师

导师资格

博士研究生指导教师

学科专业

生物医学工程

联系方式

电话：021-64377134

E-mail：yilaishu@163.com

一、个人简介

舒易来为教授、主任医师，哈佛大学医学院博士后，国家杰出青年科学基金项目、优秀青年科学基金项目获得者，现为复旦大学附属眼耳鼻喉科医院耳鼻喉科研究院副院长、医工交叉创新研究院副院长、遗传性耳聋诊治中心主任。以临床需求为导向，聚焦耳聋机制、防治及临床研究，并取得多项创新性成果，包括：1）发现GJB2、SLC26A4等耳聋基因致病新机制。2）研发基因编辑、基因替代等遗传性耳聋新疗法；开发药物性、噪声性耳聋防治及毛细胞、鼓膜再生的新策略。3）成功开展全球首个遗传性耳聋临床试验，成功纠正多例患儿听力，该成果发表于顶级期刊柳叶刀，是听觉领域的重大突破。成立基因和细胞治疗中心、遗传性耳聋诊治中心，与生殖中心共建出生缺陷联盟；牵头制定遗传性耳聋基因治疗专家共识，参与制定中国听神经病临床实践指南。近5年以通讯作者发表50余篇文章，包括TheLancet、TheBMJ、SciTransl Med、Neuron、CellRes等国际知名杂志。主持国自然杰青、优青、面上，科技部重点研发课题，上海市科委、教委重大等课题。并获中国医院协会医院科技创新奖、华夏青年医学科技奖、“春昇杯”医学创新人才大赛成长组一等奖、上海医学科技奖二等奖、上海市卫生系统第十七届“银蛇奖”、上海市青年五四奖章、上海市卫健委“医苑新星”杰出青年等。

二、主要学习与工作经历

学习经历：

2010/10-2012/06，哈佛大学医学院，联合培养博士

2007/09-2012/06，复旦大学，耳鼻咽喉科学，硕博连读

1999/09-2004/07，南华大学，临床医学，本科

工作经历：

2022/12-至今，复旦大学，教授

2022/12-至今，复旦大学附属眼耳鼻喉科医院，主任医师

2018/12-至今，复旦大学，研究员

2017/11-2022/12，复旦大学附属眼耳鼻喉科医院，副主任医师

  1. 主要科研工作与成绩

代表性论文（通讯作者）：

  1. LvJun; Wang Hui; Cheng Xiaoting; Chen Yuxin; Wang Daqi; ZhangLonglong; Cao Qi; Tang Honghai; Hu Shaowei; Gao Kaiyu; XunMengzhao; Wang Jinghan; Wang Zijing; Zhu Biyun; Cui Chong; GaoZiwen; Guo Luo; Yu Sha; Jiang Luoying; Yin Yanbo; Zhang Jiajia;Chen Bing; Wang Wuqing; Chai Renjie; Chen Zheng-Yi; Li Huawei;ShuYilai.AAV1-hOTOF gene therapy for autosomal recessive deafness 9: asingle-arm trial. The Lancet[J].2024, S0140-6736(23)02874-X.Advance online publication.

  2. ChengXiaoting; Peng Kevin A.; Chen Bing; ShuYilai.A teenager with auricular infection secondary to piercing.Bmj-British Medical Journal [J]. 2023, 380.

  3. XiaoQingquan; Xu Zhijiao; Xue Yuanyuan; Xu Chunlong; Han Lei; LiuYuanhua; Wang Fang; Zhang Runze; Han Shuang; Wang Xing; LiGeng-Lin; Li Huawei; Yang Hui; ShuYilai.Rescue of autosomal dominant hearing loss by in vivo delivery ofmini dCas13X-derived RNA base editor. Science TranslationalMedicine [J]. 2022, 14(654).

  4. GuXi; Hu Xinde; Wang Daqi; Xu Zhijiao; Wang Fang; Li Di; LiGeng-Lin; Yang Hui; Li Huawei; Zuo Erwei; ShuYilai.Treatment of autosomal recessive hearing loss via in vivoCRISPR/Cas9-mediated optimized homology-directed repair in mice.Cell Research [J]. 2022, 32(7): 699-702.

  5. ZhengZiwen; Li Guo; Cui Chong; Wang Fang; Wang Xiaohan; Xu Zhijiao;Guo Huiping; Chen Yuxin; Tang Honghai; Wang Daqi; Huang Mingqian;Chen Zheng-Yi; Huang Xingxu; Li Huawei; Li Geng-Lin; HuXiaoxiang; ShuYilai.Preventing autosomal-dominant hearing loss in Bth mice withCRISPR/CasRx-based RNA editing. Signal Transduction and TargetedTherapy [J]. 2022, 7(1).

  6. XueYuanyuan; Hu Xinde; Wang Daqi; Li Di; Li Yige; Wang Fang; HuangMingqian; Gu Xi; Xu Zhijiao; Zhou Jinan; Wang Jinghan; ChaiRenjie; Shen Jun; Chen Zheng-Yi; Li Geng-Lin; Yang Hui; LiHuawei; Zuo Erwei; ShuYilai.Gene editing in a Myo6 semi-dominant mouse model rescues auditoryfunction. Molecular Therapy [J]. 2022, 30(1): 105-118.

  7. LiuQianying;ZhangXiang;HuangHui;ChenYuxin;WangFang;HaoAihua;ZhanWuqiang;MaoQiyu;HuYuxia;HanLin;SunYifang;ZhangMeng;LiuZhimin;LiGenglin;ZhangWeijia;ShuYilai;SunLei;ChenZhengguo.Asymmetric pendrin homodimer reveals its molecularmechanism as anion exchanger. Nature communications[J]. 2023,14(1): 3012.

  8. ZhengYou; Liu Heng; Chen Yuxin; Dong Shaowei; Wang Fang; Wang Shengyi;Li Geng-Lin; ShuYilai;Xu Fei. Structural insights into the lipid and ligand regulationof a human neuronal KCNQ channel. Neuron [J]. 2022, 110(2):237-+.

  9. LiQing; Cui Chong; Liao Rongyu; Yin Xidi; Wang Daqi; Cheng Yanbo;Huang Bowei; Wang Liqin; Yan Meng; Zhou Jinan; Zhao Jingjing;Tang Wei; Wang Yingyi; Wang Xiaohan; Lv Jun; Li Jinsong; LiHuawei; and ShuYilai.Thepathogenesis of common Gjb2 mutations associated with humanhereditary deafness in mice. Cellular and molecular lifesciences[J]. 2023 May 13;80(6):148.

  10. CuiChong; Wang Daqi; Huang Bowei; Wang Fang; Chen Yuxin; Lv Jun;Zhang Luping; Han Lei; Liu Dong; Chen Zheng-Yi; Li Geng-Lin; LiHuawei; ShuYilai.Precise detection of CRISPR-Cas9 editing in hair cells in thetreatment of autosomal dominant hearing loss. MolecularTherapy-Nucleic Acids [J]. 2022, 29: 400-412.

  11. TangHonghai; Wang Hui; Wang Shengyi; Hu Shao Wei; Lv Jun; XunMengzhao; Gao Kaiyu; Wang Fang; Chen Yuxin; Wang Daqi; WangWuqing; Li Huawei; ShuYilai.Hearing of Otof-deficient mice restored by trans-splicing of N-and C-terminal otoferlin. Human Genetics [J]. 2023, 142(2):289-304.

  12. ZhangLonglong;WangHui;XunMengzhao;TangHonghai;WangJinghan;LvJun;ZhuBiyun;ChenYuxin;WangDaqi;HuShaowei;GaoZiwen;LiuJianping;ChenZhengyi;ChenBing;Lihuawei;ShuYilai.Preclinical evaluation of the efficacy and safety of AAV1-hOTOFin mice and nonhuman primates. Molecular therapy Methods &clinical development [J]. 2023, 31: 101154.

  13. WangJiali; Wang Chong; Wang Qiao; Zhang Zhuohao; Wang Hui; WangShengyi; Chi Zhangcai; Shang Luoran; Wang Wuqing; ShuYilai.Microfluidic Preparation of Gelatin Methacryloyl Microgels asLocal Drug Delivery Vehicles for Hearing Loss Therapy. AcsApplied Materials & Interfaces [J]. 2022.

  14. GuoYang; Han Lei; Han Shuang; Tang Honghai; Wang Shengyi; Cui Chong;Chen Bing; Li Huawei; ShuYilai.Specific knockdown of Htra2 by CRISPR-CasRx prevents acquiredsensorineural hearing loss in mice. Molecular Therapy-NucleicAcids [J]. 2022, 28: 643-655.


四、主要社会学术团体兼职

1.中华医学会耳鼻咽喉头颈外科学分会第十三届委员会委员

2.上海市医学会耳鼻咽喉头颈外科专科分会第二十届委员会委员

3.第十二届中国生物物理学会听觉、言语和交流研究分会常务委员

4.中国听力医学发展基金会听觉医学创新与转化专家委员会主任委员

5.上海市医学会罕见病专科分会第四届委员会委员

五、主要研究方向

1.耳聋助听设备研发

2.耳聋的基因治疗

六、全日制专业学位联合培养单位

复旦大学


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